In the widely accepted model of neurogenesis in Drosophila, neuroblasts divide asymmetrically both to self renew and to produce a smaller progenitor cell. This cell then divides into two daughter cells, which receive cell fate determinants, causing them to exit the cell cycle and differentiate.
In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically. A research team from the University of Basel, Switzerland set out to study whether specific Drosophila neural stem cells, neuroblasts, might increase the number of cells generated in the larval brain via a similar mechanism.
The team used cell lineage tracing and genetic marker analysis to show that surprisingly large neuroblast lineages are present in the dorsomedial larval brain – a result, they say, of amplified neuroblast proliferation mediated through intermediate progenitors.
In the novel mechanism postulated by the researchers, there are intermediate progenitors present that divide symmetrically in terms of morphology, but asymmetrically in molecular terms. This latter feature means that cell fate determinants are segregated into only one daughter cell, leaving the other free to divide several more times, thus amplifying the number of cells generated.
The authors write: “The surprising similarities in the patterns of neural stem and intermediate progenitor cell division in Drosophila and mammals, suggest that amplification of brain neurogenesis in both groups of animals may rely on evolutionarily conserved cellular and molecular mechanisms.”
Closing the carbon loop
08.12.2016 | University of Pittsburgh
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
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