In the widely accepted model of neurogenesis in Drosophila, neuroblasts divide asymmetrically both to self renew and to produce a smaller progenitor cell. This cell then divides into two daughter cells, which receive cell fate determinants, causing them to exit the cell cycle and differentiate.
In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically. A research team from the University of Basel, Switzerland set out to study whether specific Drosophila neural stem cells, neuroblasts, might increase the number of cells generated in the larval brain via a similar mechanism.
The team used cell lineage tracing and genetic marker analysis to show that surprisingly large neuroblast lineages are present in the dorsomedial larval brain – a result, they say, of amplified neuroblast proliferation mediated through intermediate progenitors.
In the novel mechanism postulated by the researchers, there are intermediate progenitors present that divide symmetrically in terms of morphology, but asymmetrically in molecular terms. This latter feature means that cell fate determinants are segregated into only one daughter cell, leaving the other free to divide several more times, thus amplifying the number of cells generated.
The authors write: “The surprising similarities in the patterns of neural stem and intermediate progenitor cell division in Drosophila and mammals, suggest that amplification of brain neurogenesis in both groups of animals may rely on evolutionarily conserved cellular and molecular mechanisms.”
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
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18.01.2017 | Life Sciences