The Uukuniemi virus is the first bunyavirus whose structure researchers have been able to determine. Together with more detailed studies of the viral membrane proteins, knowledge of the Uukuniemi virus may provide a basis for development of drugs for treating bunyavirus diseases, such as hemorrhagic fever and encephalitis.
The findings were published in PNAS on the 12th February, 2008.
The researchers solved the three-dimensional structure of the virus particle, which is only 0.0001 mm in diameter, using electron tomography and computational methods. The newly determined virus structure also serves as a model for the other bunyaviruses. Recent research surprisingly revealed that the viral membrane proteins protruding as spikes from the Uukuniemi virus surface changed their shape in an acidic environment. This phenomenon is reminiscent of the mechanism whereby influenza and dengue viruses enter their host cells. The observation helps to explain how bunyaviruses infect their host cells.
The Uukuniemi virus was first isolated in the village of Uukuniemi, Finland in the early ’60s. Since then, it has proven to be an excellent model virus. Not being a human pathogen, the Uukuniemi virus is safe to work with, and yet it is very similar to many pathogenic bunyaviruses.
The Bunyaviridae viral family comprises more than 300 members and they are found worldwide. Many members of the family cause serious disease, such as hemorrhagic fever and encephalitis, for which no vaccines are available yet. Most of the bunyaviruses are transmitted by mosquitoes and ticks. The exception is hantaviruses, which belong to the Bunyaviridae family, and which are spread by voles and other rodents.
More information: Dr. Juha Huiskonen firstname.lastname@example.org
Kirsikka Mattila | alfa
Rutgers scientists discover 'Legos of life'
23.01.2018 | Rutgers University
Researchers identify a protein that keeps metastatic breast cancer cells dormant
23.01.2018 | Institute for Research in Biomedicine (IRB Barcelona)
Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
23.01.2018 | Life Sciences
23.01.2018 | Earth Sciences
23.01.2018 | Physics and Astronomy