Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists move closer to developing a new class of asthma and allergy drugs

15.02.2008
A team of Biotechnology and Biological Sciences Research Council (BBSRC) funded scientists has moved a step closer to developing a new class of effective asthma and allergy drugs.

With new research published today (15 February) in The Journal of Immunology, the team from Barts and The London School of Medicine and Dentistry has found an important target that holds significant promise for millions of people suffering from allergies, asthma, rheumatoid arthritis and a range of other inflammatory diseases. This work confirms that a key component of the body's own response to allergy-causing agents (allergens) can be targeted to reduce allergic reactions in mice.

At present, the majority of treatments for asthma and allergies focus on reducing symptoms such as an inflamed airway or runny nose and itchy eyes. Because allergies are essentially an over-the-top immune response to allergens (such as dust, peanuts, or insect bites), it is possible to give a treatment that dampens down the immune system. However this is very risky, leaving the person vulnerable to infection, and so is only used in the most extreme cases - for most people treatments that manage the symptoms of allergy are the best option. The BBSRC team led by Professor Bart Vanhaesebroeck has shown that by targeting a molecule called p110delta it is possible to interfere in the allergic reaction before symptoms occur, but without shutting down the immune system.

p110delta is a member of a family of eight proteins called PI3Ks, which control important biological functions. Their activity is implicated in many different diseases including cancer and they are an important target for drugs. However, drugs that act on all PI3K family members tend to be toxic in the body. For this reason Professor Vanhaesebroeck's team uses genetic techniques to find out which PI3K family members are linked to specific diseases. By gaining a better understanding of each PI3K they hope to target drugs more specifically and reduce the potential for side effects.

... more about:
»Allergic »Allergy »Asthma »PI3K »p110delta »reaction »symptoms

The p110gamma member of the PI3K family had previously been implicated in allergic reactions and was thought to be more important than p110delta. However, in the current study, Prof Vanhaesebroeck's team has confirmed that p110delta, but not p110gamma, is important for allergic reactions in a mouse model. These results will help to inform and drive decisions in industry to prioritise which PI3K family members should be targeted for further investment and development. The next step to develop p110delta blockers is now ongoing in industry, and is expected to proceed into the preclinical arena in humans in the near future.

Lead author of the study, Dr Khaled Ali said: "p110delta was first identified in 1997 and, and although we had our suspicions, at that time we had no idea how important it would turn out to be. This work shows that we have the potential to take control of the body's reaction to an allergen and prevent symptoms from occurring."

Professor Vanhaesebroeck added: "This work confirms our previous findings and shows once and for all that in an allergic reaction it is p110delta that is the key player among the PI3K molecules. We are very hopeful that a drug for human patients can be developed in the very near future. This approach offers the potential for therapies for asthma and allergies that target the real causes, not just symptoms."

Professor Nigel Brown, BBSRC Director of Science and Technology, said: "Allergies alone cause misery for millions every year and is of significant cost the UK due to lost productivity. This research, basic bioscience funded by BBSRC, together with industry collaboration could mean an entirely new way of dealing with asthma and allergies."

Press Office | alfa
Further information:
http://www.bbsrc.ac.uk
http://www.bbsrc.ac.uk/media

Further reports about: Allergic Allergy Asthma PI3K p110delta reaction symptoms

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>