Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

2 genes found to play crucial role in cell survival

06.02.2008
New research suggests that two recently discovered genes are critically important for controlling cell survival during embryonic development.

The genes, called E2F7 and E2F8, are the least understood members of a family of genes that play a fundamental role in animal development. Members of this family are also involved in cancers of the breast, bladder, stomach and colon.

This animal study showed that complete loss of the two genes causes massive cell death and is lethal in developing embryos.

It also showed that the two genes prevent this cell death largely by suppressing the activity of another member of the family, called E2f1. This third gene is known to play an important role in triggering programmed cell death, or apoptosis, in embryos.

... more about:
»Development »E2f1 »embryos »survival

The findings by researchers at the Ohio State University Comprehensive Cancer Center are published in the Jan. 15 issue of the journal Developmental Cell, with an accompanying commentary.

“Until now, almost nothing was known about the function of these two genes in animals,” says principal investigator Gustavo Leone, an associate professor of molecular virology, immunology and medical genetics at Ohio State’s Comprehensive Cancer Center.

“Our study not only shows that both these genes are critical for embryonic development, but also how members of this gene family work together to regulate cell survival and proliferation.”

Leone and his colleagues used mice that were missing either E2f7 or E2f8, or both genes, and mice missing both genes and the E2f1 gene.

Their experiments showed that embryos survived, and massive cell death was prevented, if they had at least one copy (of the normal two) of either of the two genes.

When the two genes were entirely missing, however, massive cell death and other problems occurred that were lethal before birth. On the other hand, embryos that were completely missing both genes and missing the E2f1 gene, did not show the massive cell death, although they also died before birth. “This of course means that E2f7 and E2f8 are doing more than just regulating cell death, and we are now exploring new avenues of their function,” Leone says.

“Overall,” he says, “our findings indicate that these two genes are essential for embryonic development and for preventing widespread cell death, mainly by targeting the E2f1 gene.”

Darrell E. Ward | EurekAlert!
Further information:
http://www.osumc.edu

Further reports about: Development E2f1 embryos survival

More articles from Life Sciences:

nachricht Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>