Their paper published in the Royal Society of Chemistry's Chemical Communications has been tagged as a hot article. Dr Paradisi and her co-workers used an enzyme called horse liver alcohol dehydrogenase to drive a process known as dynamic kinetic resolution (DKR). The researchers believe that this process could be applied to the synthesis of the Profen class of pharmaceutical products and that it represents a real move toward environmentally-friendly chemical processes.
The precursor to Ibuprofen, one of the most commonly used anti-inflammatory agents, is Ibuprofenol, which is a member of a class of molecules called arylpropanols. These molecules like many in nature occur in two forms; these are mirror images known as R and S, like right and left. But the biological activity of Ibuprofen is mainly due to the S form. Using conventional processes for preparing pure S-Ibuprofenol, a maximum conversion of only 50% is possible which is wasteful both economically and environmentally.
Kinetic resolution is based on the idea that the two forms of the molecules react at different rates. With DKR, it is possible to theoretically achieve 100% completion because both R and S forms of the starting material form a chemical equilibrium and exchange. In this way the faster reacting S form is replenished in the course of the reaction at the expense of the slower reacting R form, giving higher yields of the desired product.
Enzymes as biocatalysts offer many advantages over conventional chemical catalysts. The use of purified enzymes as reagents for organic synthesis is an important step in the development of environmentally benign or "greener" chemical processes.
Claire Twomey | alfa
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In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
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