Their paper published in the Royal Society of Chemistry's Chemical Communications has been tagged as a hot article. Dr Paradisi and her co-workers used an enzyme called horse liver alcohol dehydrogenase to drive a process known as dynamic kinetic resolution (DKR). The researchers believe that this process could be applied to the synthesis of the Profen class of pharmaceutical products and that it represents a real move toward environmentally-friendly chemical processes.
The precursor to Ibuprofen, one of the most commonly used anti-inflammatory agents, is Ibuprofenol, which is a member of a class of molecules called arylpropanols. These molecules like many in nature occur in two forms; these are mirror images known as R and S, like right and left. But the biological activity of Ibuprofen is mainly due to the S form. Using conventional processes for preparing pure S-Ibuprofenol, a maximum conversion of only 50% is possible which is wasteful both economically and environmentally.
Kinetic resolution is based on the idea that the two forms of the molecules react at different rates. With DKR, it is possible to theoretically achieve 100% completion because both R and S forms of the starting material form a chemical equilibrium and exchange. In this way the faster reacting S form is replenished in the course of the reaction at the expense of the slower reacting R form, giving higher yields of the desired product.
Enzymes as biocatalysts offer many advantages over conventional chemical catalysts. The use of purified enzymes as reagents for organic synthesis is an important step in the development of environmentally benign or "greener" chemical processes.
Claire Twomey | alfa
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
The pyrenoid is a carbon-fixing liquid droplet
22.09.2017 | Max-Planck-Institut für Biochemie
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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22.09.2017 | Life Sciences
22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy