Their paper published in the Royal Society of Chemistry's Chemical Communications has been tagged as a hot article. Dr Paradisi and her co-workers used an enzyme called horse liver alcohol dehydrogenase to drive a process known as dynamic kinetic resolution (DKR). The researchers believe that this process could be applied to the synthesis of the Profen class of pharmaceutical products and that it represents a real move toward environmentally-friendly chemical processes.
The precursor to Ibuprofen, one of the most commonly used anti-inflammatory agents, is Ibuprofenol, which is a member of a class of molecules called arylpropanols. These molecules like many in nature occur in two forms; these are mirror images known as R and S, like right and left. But the biological activity of Ibuprofen is mainly due to the S form. Using conventional processes for preparing pure S-Ibuprofenol, a maximum conversion of only 50% is possible which is wasteful both economically and environmentally.
Kinetic resolution is based on the idea that the two forms of the molecules react at different rates. With DKR, it is possible to theoretically achieve 100% completion because both R and S forms of the starting material form a chemical equilibrium and exchange. In this way the faster reacting S form is replenished in the course of the reaction at the expense of the slower reacting R form, giving higher yields of the desired product.
Enzymes as biocatalysts offer many advantages over conventional chemical catalysts. The use of purified enzymes as reagents for organic synthesis is an important step in the development of environmentally benign or "greener" chemical processes.
Claire Twomey | alfa
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
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In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
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By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
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COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
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