Chronic lymphocytic leukemia (CLL)-the most common form of leukemia in adults-arises from a special type of white blood corpuscle, B lymphocytes, which normally produce antibodies to combat bacteria and viruses that we are exposed to. It is not known today what events lead to this disease.
A research team headed by Anders Rosén, professor of cell biology at Linköping University, has now established for the first time that the antibodies that CLL cells produce are highly specialized to recognize certain structures on the surface of bacteria and the body's own proteins (autoantigens).
The findings are being published on Monday in the respected hematological journal Blood. The key point is that the CLL antibodies also bind to damaged and dying (apoptotic) cells, which indicates that the B lymphocytes that give rise to CLL may be frontline defense cells. These are thought to have the extremely important task of using their antibodies to rapidly reveal the slightest breach in damaged mucous lining or skin, created by bacteria or other microorganisms.
But in long-term infections, these B lymphocytes can start to multiply excessively and rapidly. This increases the risk of chromosome damage, which in turn can cause them to turn into leukemia cells. The study now being published contributes to our understanding of how these B lymphocytes function and why they can be transformed into tumors.
CLL afflicts 400-500 people in Sweden each year, primarily among those aged 65-70 and more often among men than women. The disease has a highly varied course, with many patients living for decades with hardly any treatment, while others die within a few years despite treatment.
The research team behind the study also includes the doctoral students Eva Hellqvist and Anna Lanemo-Myrhinder, Linköping University, and Sohvi Hörkkö, Oulu, Finland, and Richard Rosenquist, Uppsala, Sweden.
The article, "A new perspective: molecular motifs on oxidized-LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies" is being published in Blood's First Edition Papers.
Contact: Anders Rosén, phone: +46 (0)13-222794; cell phone: +46 (0)707-303460, firstname.lastname@example.org
Pressofficer Åke Hjelm; email@example.com; +46-13 281 395
Åke Hjelm | idw
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Interdisciplinary Research
20.10.2017 | Materials Sciences
20.10.2017 | Earth Sciences