Chronic lymphocytic leukemia (CLL)-the most common form of leukemia in adults-arises from a special type of white blood corpuscle, B lymphocytes, which normally produce antibodies to combat bacteria and viruses that we are exposed to. It is not known today what events lead to this disease.
A research team headed by Anders Rosén, professor of cell biology at Linköping University, has now established for the first time that the antibodies that CLL cells produce are highly specialized to recognize certain structures on the surface of bacteria and the body's own proteins (autoantigens).
The findings are being published on Monday in the respected hematological journal Blood. The key point is that the CLL antibodies also bind to damaged and dying (apoptotic) cells, which indicates that the B lymphocytes that give rise to CLL may be frontline defense cells. These are thought to have the extremely important task of using their antibodies to rapidly reveal the slightest breach in damaged mucous lining or skin, created by bacteria or other microorganisms.
But in long-term infections, these B lymphocytes can start to multiply excessively and rapidly. This increases the risk of chromosome damage, which in turn can cause them to turn into leukemia cells. The study now being published contributes to our understanding of how these B lymphocytes function and why they can be transformed into tumors.
CLL afflicts 400-500 people in Sweden each year, primarily among those aged 65-70 and more often among men than women. The disease has a highly varied course, with many patients living for decades with hardly any treatment, while others die within a few years despite treatment.
The research team behind the study also includes the doctoral students Eva Hellqvist and Anna Lanemo-Myrhinder, Linköping University, and Sohvi Hörkkö, Oulu, Finland, and Richard Rosenquist, Uppsala, Sweden.
The article, "A new perspective: molecular motifs on oxidized-LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies" is being published in Blood's First Edition Papers.
Contact: Anders Rosén, phone: +46 (0)13-222794; cell phone: +46 (0)707-303460, email@example.com
Pressofficer Åke Hjelm; firstname.lastname@example.org; +46-13 281 395
Åke Hjelm | idw
Closing the carbon loop
08.12.2016 | University of Pittsburgh
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
08.12.2016 | Life Sciences
08.12.2016 | Physics and Astronomy
08.12.2016 | Materials Sciences