Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Evolutionary phenomenon in mice may explain human infertility

25.01.2008
Scientists at the University of Liverpool have found that field mice have evolved a unique way of ensuring faster fertilisation, a phenomenon which could explain some cases of infertility in humans.

The team, in collaboration with Charles University, Prague, found that field mice sacrifice some of their immunity protection in favour of a more rapid fertilisation process. This occurs due to the absence of a protein, called CD46. Present in both animals and humans, it helps protect the body’s cells from attack by its immune system. Over time, field mice have lost the ability to produce this protein, resulting in instability of a cap-like structure, called the acrosome, present over the head of the sperm.

This instability allows the acrosome to be shed from the sperm head to create a new surface essential for sperm to be capable of fusing with an egg. This is a natural process that can take days to occur in humans, but field mice have developed a way in which this can occur rapidly.

Immunologist, Professor Peter Johnson, explains: “Field mice have traded the production of an immunologically important protein in favour of this faster fertilization process in order to compete with other mice more successfully. Female mice produce multiple eggs and if there are a lot of male mice competing for her, then it is an advantage to an individual mouse for its sperm to react quickly in order to beat other male competitors to fertilisation.”

... more about:
»EGG »fertilisation »infertility »sperm

“By improving our understanding of defects in CD46 we may improve treatments for infertility in men. Humans normally produce a single egg each month and there is no evolutionary necessity to develop rapid sperm reaction to egg fertilisation. The process is therefore much slower and so any defect in CD46 could result in sperm being destabilised too early.

“Interestingly the rapid reaction caused in mice is similar to that in IVF treatment in humans where the acronome is artificially expelled from the sperm head before it is introduced to the egg to speed up the fertilisation process. Field mice appear to do this naturally.”

Samantha Martin | EurekAlert!
Further information:
http://www.liv.ac.uk

Further reports about: EGG fertilisation infertility sperm

More articles from Life Sciences:

nachricht New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego

nachricht Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Gran Chaco: Biodiversity at High Risk

17.01.2018 | Ecology, The Environment and Conservation

Only an atom thick: Physicists succeed in measuring mechanical properties of 2D monolayer materials

17.01.2018 | Physics and Astronomy

Fraunhofer HHI receives AIS Technology Innovation Award 2018 for 3D Human Body Reconstruction

17.01.2018 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>