The team, in collaboration with Charles University, Prague, found that field mice sacrifice some of their immunity protection in favour of a more rapid fertilisation process. This occurs due to the absence of a protein, called CD46. Present in both animals and humans, it helps protect the body’s cells from attack by its immune system. Over time, field mice have lost the ability to produce this protein, resulting in instability of a cap-like structure, called the acrosome, present over the head of the sperm.
This instability allows the acrosome to be shed from the sperm head to create a new surface essential for sperm to be capable of fusing with an egg. This is a natural process that can take days to occur in humans, but field mice have developed a way in which this can occur rapidly.
Immunologist, Professor Peter Johnson, explains: “Field mice have traded the production of an immunologically important protein in favour of this faster fertilization process in order to compete with other mice more successfully. Female mice produce multiple eggs and if there are a lot of male mice competing for her, then it is an advantage to an individual mouse for its sperm to react quickly in order to beat other male competitors to fertilisation.”
“By improving our understanding of defects in CD46 we may improve treatments for infertility in men. Humans normally produce a single egg each month and there is no evolutionary necessity to develop rapid sperm reaction to egg fertilisation. The process is therefore much slower and so any defect in CD46 could result in sperm being destabilised too early.
“Interestingly the rapid reaction caused in mice is similar to that in IVF treatment in humans where the acronome is artificially expelled from the sperm head before it is introduced to the egg to speed up the fertilisation process. Field mice appear to do this naturally.”
Samantha Martin | EurekAlert!
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News