New Use Found for DNA as an Artificial Nose
In designing artificial noses modeled after biological olfaction, the challenge has been to generate a similarly large sensor repertoire with the requisite combinatorial complexity to detect odors in the real world. A further requirement is that the sensors can be manufactured with exact chemical precision and reproducibility.
In a new study published this week in the open-access journal PLoS Biology, Joel White, Mary AtKisson, John Kauer and colleagues demonstrate a previously unreported property of deoxyribonucleic acid. The researchers show that single-stranded DNA molecules tagged with a fluorescent reporter and dried onto solid surfaces can respond to vapor phase odor pulses in a sequence-selective manner.
In the context of detecting chemicals in either the aqueous or vapor phase, two general biological approaches have emerged. The first relies on individual, highly specific single receptors (sensors), each tuned to detect a single molecular species. Some examples include the receptors that mediate pheromone detection in insects, or those that function in neurotransmission.
The second approach, represented by the DNA sensors, is implemented by arrays of receptors with relatively broad responses. Here, specificity emerges from a constellation of receptor types that recognizes the molecule of interest. An example is the olfactory receptors in the main olfactory system of vertebrates.
This study not only highlights DNA’s potential for use in a novel and powerful odor detection system, but it also highlights its potential to play other novel roles in vivo, for example as a small molecule receptor, well outside of its familiar one as the repository of information in the genome.
Andrew Hyde | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
New success for Konstanz physicists in studying the quantum vacuum
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...