SLE (systemic lupus erythematosus) is a so-called autoimmune disease, meaning that the immune defense system attacks the body. SLE primarily affects young women and can lead to severe kidney failure, blood clots, and miscarriages, among other things.
A research team at Uppsala University directed by Associate Professor Marta E. Alarcón-Requelme has identified a new gene, BANK1, that is important to our understanding of how SLE arises and that may also come to be of significance for treatment. The gene affects the body’s B cells, which in turn produce the auto-antibodies that attack the body.
“The new treatments of SLE that have been developed primarily target the elimination of B cells. With the help of the gene we have now identified, in the future it may be possible to regulate the functions of B cells,” says Marta E. Alarcón-Requelme.
Moreover, her research team, working together with American and British colleagues, has performed a complete scan of the genome of 1,800 European and American SLE patients and thereby managed to identify a number of other genes that regulate the disease. All of these findings are now being published in three separate articles in the February issue of the scientific journal Nature Genetics and are already available in the Web version of the journal.
Read the articles:
The B Cell Gene BANK1 is Associated with Systemic Lupus Erythematosus Through the Effect of Several Functional Variants http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.79.html
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.81.htmlA non-synonymous functional variant in Integrin-a-M (ITGAM) is associated with systematic lupus erythematosus (SLE)
For more information, please contact Marta E. Alarcón-Riquelme, phone: +46 (0)18-471 48 05; cell phone: +46 (0)70-167 91 09, e-mail: firstname.lastname@example.org, home page: http://www.genpat.uu.se/en/node126
Anneli Waara | alfa
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences