Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

USC researchers identify mechanism that controls activation of stem cells during hair regeneration

18.01.2008
New 'dermal clock' signaling coordinates stem cell activity in a population of hair follicles

Researchers at the University of Southern California (USC) have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models. The signaling switch involves bone morphogenetic protein (Bmp) pathway, according to the study that will be published in the Jan. 17 issue of the journal Nature.

"Conceptually, the findings have important implications for stem cell research and in understanding how stem cell activity is regulated during regeneration," says Cheng-Ming Chuong, M.D., Ph.D., principal investigator and professor of pathology at the Keck School of Medicine of USC. "The research presents a new dimension for the regulation of hair re-growth and ultimately organ regeneration."

The hair is an important model for organ regeneration in mammals because it is one of the few organs that regenerate regularly, Chuong notes. Recent work in the field has established hair cycling as one of the mainstream models for organ regeneration. However, most of these works focus on the cyclic regeneration of one single hair follicle, he says.

... more about:
»Chuong »Regeneration »USC »activation »follicle

"Each of us has thousands of hair follicles. In our study, we were motivated to analyze the coordinative behavior of cyclic regeneration in a population of organs," Chuong says.

The research team found that hairs, even in normal mice, regenerate in waves, rather than individually. The findings suggest that hair stem cells are regulated not only by the micro-environment within one hair follicle -- as has previously been thought -- but also by adjacent hair follicles, other skin compartments and systemic hormones, in a hierarchical order.

At the molecular level, the findings showed that periodic expression of Bmp in the skin macro-environment appears to be at the center of the mechanism for coordinated hair stem cell activation. When many hairs regenerate, they must communicate activation signals among themselves. At different time points the macro-environment can be either permissive or suppressive for stem cell activation.

"Our research shows that the formation of new tissues or organs from stem cells -- such as the formation of new hairs -- can be more robust if it occurs in a permissive macro-environment," says Maksim Plikus, Ph.D., a post-doctoral fellow and the first author of the study. "I hope that our research will draw more attention to the hair follicle as the model for physiological regeneration in mammals, and as an abundant source of adult stem cells for the purposes of stem cell therapy."

"The work also has critical implications for research using the mouse skin as a model for tumor growth or drug delivery," Chuong notes. "Many of these studies assume the mouse skin is a homogeneous and stable environment for testing, but variations in results were obtained. Understanding this unexpected dynamics of the living mouse skin will help their experimental designs."

Meghan Lewit | EurekAlert!
Further information:
http://www.usc.edu

Further reports about: Chuong Regeneration USC activation follicle

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Taming 'wild' electrons in graphene

23.10.2017 | Physics and Astronomy

Mountain glaciers shrinking across the West

23.10.2017 | Earth Sciences

Scientists track ovarian cancers to site of origin: Fallopian tubes

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>