Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hybridization partially restores vision in cavefish

08.01.2008
Hybridizing blind cave fish from different cave populations can partially restore the vision of their offspring, biologists at New York University have found. The study suggests that genetic engineering can override, at least in part, half a million years of evolutionary change in one generation.

“Evolution has many ways to accomplish the same end result, which in the case of cave fish is blindness,” said NYU Biology Professor Richard Borowsky, the study’s lead author. “For this reason, the genes that are mutated in one population that lead to blindness are different in other, independently evolved populations. Thus, when you cross them, the genetic deficiencies in one lineage are compensated for by strengths in the other, and vice-versa.”

The research, supported by grants from the National Science Foundation and the National Institutes of Health, appears in the most recent issue of the journal Current Biology.

The study examined four populations of blind cave fish, Astyanax mexicanus, which inhabit different caves in northeast Mexico. Blind for millennia, these fish evolved from eyed, surface fish. The researchers’ genetic analysis showed that the evolutionary impairment of eye development, as well as the loss of pigmentation and other cave-related changes, resulted from mutations at multiple gene sites.

... more about:
»Genetic »HYBRID »Restore »partially

In order to gauge how genetic make-up could bring about the restoration of vision, the researchers created hybrids of the different cave fish populations. Among these various hybrids, they found that nearly 40 percent in some hybrid crosses could see.

“These fish are descended from ancestors that have been isolated in the dark for nearly one million years and most likely haven’t had the capacity for vision for at least half that time,” said Borowsky. “But by recombining the right genes through hybridization, you can partially restore vision. Not only are the structures of the eye restored to the point where they regain function, but all the connections to the brain for proper processing of information not used for that enormous length of time are restored.”

Borowsky added that the findings could pave the way for greater understanding of human eyes.

“These genes that have had their function altered by mutation are the same genes that normally play important roles in the development and maintenance of the eye in humans as well as in fishes,” he explained. “The cave fish system gives us an experimental model for learning about human eye development and diseases.”

James Devitt | EurekAlert!
Further information:
http://www.nyu.edu

Further reports about: Genetic HYBRID Restore partially

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>