Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hybridization partially restores vision in cavefish

08.01.2008
Hybridizing blind cave fish from different cave populations can partially restore the vision of their offspring, biologists at New York University have found. The study suggests that genetic engineering can override, at least in part, half a million years of evolutionary change in one generation.

“Evolution has many ways to accomplish the same end result, which in the case of cave fish is blindness,” said NYU Biology Professor Richard Borowsky, the study’s lead author. “For this reason, the genes that are mutated in one population that lead to blindness are different in other, independently evolved populations. Thus, when you cross them, the genetic deficiencies in one lineage are compensated for by strengths in the other, and vice-versa.”

The research, supported by grants from the National Science Foundation and the National Institutes of Health, appears in the most recent issue of the journal Current Biology.

The study examined four populations of blind cave fish, Astyanax mexicanus, which inhabit different caves in northeast Mexico. Blind for millennia, these fish evolved from eyed, surface fish. The researchers’ genetic analysis showed that the evolutionary impairment of eye development, as well as the loss of pigmentation and other cave-related changes, resulted from mutations at multiple gene sites.

... more about:
»Genetic »HYBRID »Restore »partially

In order to gauge how genetic make-up could bring about the restoration of vision, the researchers created hybrids of the different cave fish populations. Among these various hybrids, they found that nearly 40 percent in some hybrid crosses could see.

“These fish are descended from ancestors that have been isolated in the dark for nearly one million years and most likely haven’t had the capacity for vision for at least half that time,” said Borowsky. “But by recombining the right genes through hybridization, you can partially restore vision. Not only are the structures of the eye restored to the point where they regain function, but all the connections to the brain for proper processing of information not used for that enormous length of time are restored.”

Borowsky added that the findings could pave the way for greater understanding of human eyes.

“These genes that have had their function altered by mutation are the same genes that normally play important roles in the development and maintenance of the eye in humans as well as in fishes,” he explained. “The cave fish system gives us an experimental model for learning about human eye development and diseases.”

James Devitt | EurekAlert!
Further information:
http://www.nyu.edu

Further reports about: Genetic HYBRID Restore partially

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>