Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Important medical breakthrough for organ transplants and cardiovascular diseases: Flemish researchers overcome oxygen deficiency

07.01.2008
No life without oxygen - but oxygen can also be harmful

Oxygen is necessary to life. Humans and animals use oxygen to convert fats and sugars into the energy that keeps all life processes running and maintains the body’s temperature. At the same time, oxygen can also be harmful when it is converted into toxic oxygen particles that cause serious damage to tissues and organs.

What about a little less?
Some animals can survive in places with little oxygen. Birds at high altitudes, for example, or animals that live underground or that can dive under water for a long time. Hibernating animals turn their bodily processes down low and live with a reduced amount of oxygen.

We can detect changes in the amount of oxygen with certain sensors. These oxygen meters are essential in adapting the body’s metabolism during the changeover from an oxygen-rich to an oxygen-deficient environment.

... more about:
»Organ »Oxygen »PhD1 »deficiency
Oxygen meter PHD1 plays crucial role
Julián Aragonés, Martin Schneider, Katie Van Geyte and Peter Fraisl - under the direction of Peter Carmeliet - have studied the role of the PHD1 oxygen meter. To do this, they used ‘knock-out’ mice that were unable to produce PHD1. They found that blocking an artery in these mice - thus obstructing the oxygen supply to the muscle - did not lead to the death of the surrounding muscular tissue. This was a very surprising result, since the muscle received too little oxygen to survive under normal circumstances. In the mice lacking the PHD1 oxygen meter, the tissue apparently ‘reprogrammed’ itself by means of a metabolic shift, so that the muscle needed less oxygen in order to continue to function. Furthermore, less oxygen in the muscle meant fewer toxic oxygen particles and thus less damage. So, the muscle could use the little oxygen that was available in a better and safer manner. These alterations enabled the muscle to stay perfectly healthy in these normally life-threatening conditions. In addition, the researchers also demonstrated that treating healthy mice even briefly with a PHD1-blocker could protect the muscles against oxygen deficiency - which opens a path to new therapies.
New therapeutic possibilities?
These findings have significant implications for several medical applications. Scientists can now begin to investigate whether PHD1-blockers can prevent the damage caused by blockage of a blood vessel through thrombosis or after a heart attack (in which the cardiac muscle experiences a shortage of oxygen). New treatment alternatives may also be possible for strokes, and surgeons may also be able to reduce the oxygen supply to organs for a longer period of time during many types of operations.

The absence of PHD1 might also explain the mysterious adaptations of hibernating animals, with important implications for the preservation of organs for transplant. Such tissues often have to contend with prolonged oxygen deficiency, which destroys their viability for transplantation. If these organs could be kept in a ‘hibernation’ condition, perhaps more lives could be saved...

Funding
This research has been funded by: CNIC, Deutsche Forschungsgemeinschaft, Lymphatic Research Foundation, Fond Québécois de la nature et des technologies, Federal Government Belgium, FWO, NIH, FRFC, K.U.Leuven, and VIB.
Mention both VIB and the university
When reporting this research, please always mention VIB as well as the university concerned.

This research was conducted by Julian Aragonés and colleagues in the ‘Functional genomics of cardiovascular and neurovascular biology and disease’ research group, led by Peter Carmeliet, within VIB’s Department of Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, under the direction of Désiré Collen.

Joke Comijn | alfa
Further information:
http://www.vib.be

Further reports about: Organ Oxygen PhD1 deficiency

More articles from Life Sciences:

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

nachricht Transforming plant cells from generalists to specialists
07.12.2016 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>