Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Baumann lab identifies elusive telomere RNA subunit in single cell model

03.01.2008
The Stowers Institute’s Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition.

Chromosomes shorten with every cell division. In stem cells and in cancer cells, this shortening is compensated by telomerase, an enzyme that adds short repeat sequences to the ends of chromosomes to replenish lost DNA. As telomerase is required for the continued growth of most cancer cells, the enzyme is considered a promising target for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further intensified interest in understanding telomerase and its regulation.

The RNA subunit of telomerase is of particular interest as it represents one of the two core components of telomerase and provides the template for the short repeats that are added to the ends of chromosomes. The Baumann Lab is working to understand how telomerase is assembled, how it is recruited to chromosome ends, and how its activity is regulated. These efforts may shed light on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a variety of diseases including cancer and coronary heart disease.

Telomerase RNA has been studied in a variety of simple model organisms, but telomere maintenance turned out to be quite different in these species compared to human cells. Recently, the Baumann Lab used a biochemical approach to identify and clone the RNA subunit of telomerase in Schizosaccharomyces pombe, or fission yeast.

... more about:
»Chromosome »Component »RNA »Telomerase »Telomere »subunit

“The identification of the fission yeast equivalent of the telomerase RNA gene provides us with a critical tool to study telomerase in a genetically tractable, single-cell organism with a telomere maintenance machinery that shares many features with human cells,” explained Peter Baumann, Ph.D., Assistant Investigator and senior author on the paper. “We and others had been studying telomerase activity, recruitment, and regulation for several years but the fact that the RNA subunit was unknown in our fission yeast model system severely limited our ability to make progress.”

Now that the missing component of the model system has been identified, the Baumann Lab’s structural and functional studies are expected to progress rapidly. The lab is now turning its attention to how and where telomerase is assembled from its components in the cell and what processing it must undergo to become active.

Marie Jennings | EurekAlert!
Further information:
http://www.stowers-institute.org

Further reports about: Chromosome Component RNA Telomerase Telomere subunit

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>