To try to identify pathological genes that are involved in ALS, the research group at Umeå University, in collaboration with Dutch and Belgian scientists, compared DNA samples from 1,767 patients with non-familial ALS (so-called sporadic ALS, SALS) with DNA samples from 1,916 control individuals. This is the world's most comprehensive ALS study so far. They looked for DNA mutations that only exist in ALS patients, not in controls. After very extensive analyses they found that a DNA mutation in the gene DPP6 strongly correlates with SALS.
The DPP6 gene is on chromosome number 7 and codes for a protein enzyme, a peptidase that regulates the activity of so-called neuropeptides, that is, substances that affect nerve cells. DPP6 is therefore highly interesting as a candidate gene for ALS. Studies are now concentrating on finding disease-associated mutations in the gene. Just how mutations in the DPP6 gene can lead to ALS is unknown today. At present it is not possible to judge whether the discovery will lead to any new treatment for ALS.
The Swedish component of the study was carried out by Associate Professor Peter M. Andersen, molecular geneticist Anna Birve, and research engineer Ann-Charloth Nilsson, all with the Department of Pharmacology and Clinical Neuroscience, Umeå University.
Extensive research on ALS has been pursued at Umeå University since 1992. The objective is to use new knowledge about the mechanisms behind the disease in order to develop therapies for ALS. The main focus is on molecular biological and genetic aspects of the disease and mutations in SOD1 and other genes. Resources (funding, staffing) do not allow any attempted treatment of patients at present.
The research team at Umeå consists of 23 people in four subgroups, directed by Associate Professor Peter Andersen (genetic research), Associate Professor Thomas Brännström (neuropathology), Professor Stefan Marklund (free radicals and cell research), and Associate Professor Henrik Antti (metabolomics).Contacts:
The average survival time is 2.5-3 years, but some few patients live >10 years with the disease. There is no curative treatment. As of 1996 there is a medicine that slows down the course of the disease and can extend survival by a few months.
The effect is greatest if the medicine is introduced at an early stage of the illness. Nowadays there are special ALS teams that work to provide patients and their loved ones with the best possible help.
Bertil Born | idw
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Physics and Astronomy
26.10.2016 | Earth Sciences
25.10.2016 | Earth Sciences