By contrast to traditional batch methods of production, where medications are produced one step at a time, Sipat makes continuous production possible while incorporating constant quality control.
This method of production makes it possible to save up to 20 percent on costs and to cut production time from up to two months down to about ten days. Siemens will present the new version of Sipat at Achema, the world's largest chemical industry trade fair, which will be held in Frankfurt from June 18 to 22, 2012.
Manufacturing pharmaceuticals by means of batch production methods is time consuming, cost intensive, and uses a lot of energy. One batch or "charge" of products, such as tablets or capsules, moves through the production process as a unit. The raw material must be granulated, dried, pulverized, mixed, and pressed.
The process is repeatedly halted between steps so that samples can be taken. Only when it is certain that the product is completely homogenized or the active ingredient concentration has the necessary quality is the production process continued. As a result, production can take several weeks.
If the quality of the preliminary product is not up to standard, the charge is discarded. This manufacturing technique also does not make optimal use of the production facilities.
A continuous production process is less expensive, more efficient, and uses less raw materials and energy. The automation experts at Siemens have developed the Sipat software in collaboration with large pharmaceutical companies and plant manufacturers. It is the core of a continuous production system. Sipat continuously polls process data for information about moisture content, temperature, density or grain size distribution, etc.
By correlating this information, Sipat can predict the quality of any given tablet at any point in the process. If the data from the running production threatens to exceed tolerance limits, the process can be immediately adjusted. This real-time release makes it possible to achieve a production time of about ten days.
Apart from that, continuous production makes it possible to use production facilities much more efficiently. Plant manufacturers can simply integrate the newest version V4 of Sipat into their systems.
Dr. Norbert Aschenbrenner | Siemens InnovationNews
Nerves control the body’s bacterial community
26.09.2017 | Christian-Albrechts-Universität zu Kiel
Ageless ears? Elderly barn owls do not become hard of hearing
26.09.2017 | Carl von Ossietzky-Universität Oldenburg
Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.
Graphene is up to the job
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
26.09.2017 | Life Sciences
26.09.2017 | Physics and Astronomy
26.09.2017 | Information Technology