Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Quebec Genealogical Research Provides Clues to Genetic Consequences of Human Migration Patterns

07.11.2011
The selective advantage of being on the edge of a migration wave

Research published in Science today reveals that the first individuals settling on new land are more successful at passing on their genes than those who did not migrate.

According to Dr. Damian Labuda at the University of Montréal and Sainte-Justine Hospital, the study suggests that population expansion creates opportunities for natural selection to act. The findings come from the utilization of a unique research infrastructure, the BALSAC population database which allows the reconstruction of the structure of the Quebec population over four centuries.

In this research the descending lineages of all couples married in the Charlevoix-Saguenay Lac St-Jean region between 1686 and 1960 were analyzed. This genealogy comprises more than 1 million individuals.

Dr. Laurent Excoffier, University of Berne and Swiss Institute of Bioinformatics, Dr. Damian Labuda, and Dr. Hélène Vézina, Projet BALSAC, Université du Québec à Chicoutimi, who led the study, together with research associates Claudia Moreau, Michèle Jomphe and Ph.D. student Claude Bhérer, investigated the demographic history of this region to investigate the effects of rapid territorial and demographic expansion on the dynamics of colonization and human evolution.

“We find that families who are at the forefront of a range expansion into new territories had greater reproductive success. In other words, that they had more children, and more children who also had children,” Labuda explained. “As a result, these families made a higher genetic contribution to the contemporary population than those who remained behind in what we call the range core, as opposed to the wave front.

The research confirms in humans a phenomenon that has already been observed in other species with much shorter generation spans. “We knew that the migration of species into new areas promoted the spread of rare mutations through a phenomenon known as ‘gene surfing’, but now we find that selection at the wave front could make this surfing much more efficient,” Excoffier said. This evolutionary mechanism in combination with founder effects and social or cultural transmission of reproductive behavior could explain why some genetic diseases are found at an elevated frequency in the Charlevoix and Saguenay Lac Saint-Jean regions where the study was carried out, as rare mutations can also surf during a range expansion.

“It is exciting to see how a study on a regional population of Quebec can bring insight on a human process that has been going on for thousands of years. The BALSAC population is a powerful tool for social and genetic research and this study is a very nice demonstration of its possibilities" Vézina said.

The researchers also note that, although their study concerns a whole human population spread over several centuries, it only represents a short period of human evolution at a limited geographical scale. It thus appears difficult to directly generalize these results obtained in a farmer population to what happened during other range expansions, especially considering the differences between the ecological demography of hunter-gatherer and farmer communities. But given the highly successful history of the human colonization of our planet, it appears very likely that a considerable fraction of our ancestors have lived on the edge of expansion waves. Consequently, several human traits favoring dispersal and reproduction could have evolved during phases of range expansions rather than resulting from selection in constant environments.

“This was a very productive sabbatical stay of Laurent Excoffier in Montreal, putting all our teams together, and indeed a very encouraging beginning setting stage for subsequent collaborative studies” Labuda said. Using BALSAC we plan to expand the research to other regions of Quebec and other suitable populations elsewhere.

About the study:
“Deep human genealogies reveal a selective advantage to be on an expanding wave front” was published by Claudia Moreau et al. in Science on November 3, 2011.

The study was financed in part by the Réseau de médecine génétique appliquée of the Fonds de recherche en santé du Québec.

University of Montreal, Sainte-Justine Hospital and University of Quebec at Chicoutimi are officially known as Université de Montréal, Centre hospitalier universitaire Sainte-Justine and Université du Québec à Chicoutimi, respectively.

• Damian Labuda is affiliated with Université de Montréal’s Department of Pediatrics and the Research Centre at the CHU Sainte-Justine (CR-CHUSJ).
• Laurent Excoffier is affiliated with the Institute of Ecology and Evolution at the University of Berne, and with the Swiss Institute of Bioinformatics.

• Hélène Vézina is affiliated with the Department of Human Sciences and BALSAC Project at UQAC.

William Raillant-Clark | Newswise Science News
Further information:
http://www.umontreal.ca

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>