Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Putting the Squeeze on Fat Cells

23.11.2010
TAU develops new computer method to measure mechanical stress in fat cells

From fad diets to exercise programs, Americans continue to fight the battle of the bulge. Now they'll have help from recent Tel Aviv University research that has developed a new method to look at how fat cells — which produce the fat in our bodies — respond to mechanical loads.

This might be the key to understanding how to control the amount of fat produced by fat cells, the holy grail of weight loss researchers, says Prof. Amit Gefen of Tel Aviv University's Department of Biomedical Engineering. His research is driven by the theory that fat cells, like bone or muscle cells, are influenced by mechanical loads, defined as the amount of force or deformation placed on a particular area occupied by cells. By recreating the structure of fat cells using a newly-developed computer method, Prof. Gefen and his team of researchers can determine how much mechanical load can be tolerated by fat cells, and at what point the cells will begin to disintegrate.

The research, recently reported in the Journal of Biomechanics, has direct applications in weight loss programs, the treatment of bedsores and the management of chronic diabetes.

Bones in space, fat on the ground

According to Prof. Gefen, applying mechanical loads on tissues can affect many different cells within our bodies. For example, zero gravity affects the bone density of astronauts. When astronauts return home after a prolonged space flight, he explains, they are often confined to a wheelchair for a small period of time. The structures of their bones and muscles, which are determined by the cells that produce these structures, are weakened due to a lack of mechanical loads. This occurs because cells are deprived of "normal" mechanical stimulation, like walking.

Prof. Gefen believes that, much like bone or muscle cells, fat cells are also affected by mechanical loads. His new computer model takes slices of laser confocal microscopy images of cells and reconstructs a whole, virtual version of an individual cell, allowing researchers to evaluate how that cell will respond to different mechanical stimuli. "We use these computer models to see how cells function under mechanical loading, much like simulations in structural engineering are used to test the strength of bridges or machines," he explains.

After assembling their "virtual" fat cells, Prof. Gefen and his group found that fat cells or lipids have a point where mechanical loads can disintegrate them, as well as a point at which they are able to resist disintegration. Prof. Gefen is now trying to determine the specific load magnitudes and frequencies for fat cells, perhaps using ultrasound at a supersonic frequency to vibrate the tissue.

Not all infomercials are light-weight

Those fat-busting "ab vibrators" that you can see on infomercials are on the right track, says Prof. Gefen, but the magnitude of mechanical loads and the frequency of their application need to be scientifically determined. Such information could be crucial to the future of our health, he says, noting that diabetes and obesity rates are rising. "Any treatment that would be effective in fighting obesity would also apply immediately to diabetes," he explains.

The next step for Prof. Gefen and his fellow researchers is to pin down the mathematical equations that allow for the dissolving of lipid droplets, then predict what a fat cell will do under certain levels of force. This will lead to better information on how to use mechanical loads to control the production of fat by fat cells — whether this means applying a certain frequency of ultrasonic vibration, or simply spending more time in the gym.

George Hunka | EurekAlert!
Further information:
http://www.aftau.org

More articles from Life Sciences:

nachricht Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University

nachricht Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>