Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Putting the Squeeze on Fat Cells

23.11.2010
TAU develops new computer method to measure mechanical stress in fat cells

From fad diets to exercise programs, Americans continue to fight the battle of the bulge. Now they'll have help from recent Tel Aviv University research that has developed a new method to look at how fat cells — which produce the fat in our bodies — respond to mechanical loads.

This might be the key to understanding how to control the amount of fat produced by fat cells, the holy grail of weight loss researchers, says Prof. Amit Gefen of Tel Aviv University's Department of Biomedical Engineering. His research is driven by the theory that fat cells, like bone or muscle cells, are influenced by mechanical loads, defined as the amount of force or deformation placed on a particular area occupied by cells. By recreating the structure of fat cells using a newly-developed computer method, Prof. Gefen and his team of researchers can determine how much mechanical load can be tolerated by fat cells, and at what point the cells will begin to disintegrate.

The research, recently reported in the Journal of Biomechanics, has direct applications in weight loss programs, the treatment of bedsores and the management of chronic diabetes.

Bones in space, fat on the ground

According to Prof. Gefen, applying mechanical loads on tissues can affect many different cells within our bodies. For example, zero gravity affects the bone density of astronauts. When astronauts return home after a prolonged space flight, he explains, they are often confined to a wheelchair for a small period of time. The structures of their bones and muscles, which are determined by the cells that produce these structures, are weakened due to a lack of mechanical loads. This occurs because cells are deprived of "normal" mechanical stimulation, like walking.

Prof. Gefen believes that, much like bone or muscle cells, fat cells are also affected by mechanical loads. His new computer model takes slices of laser confocal microscopy images of cells and reconstructs a whole, virtual version of an individual cell, allowing researchers to evaluate how that cell will respond to different mechanical stimuli. "We use these computer models to see how cells function under mechanical loading, much like simulations in structural engineering are used to test the strength of bridges or machines," he explains.

After assembling their "virtual" fat cells, Prof. Gefen and his group found that fat cells or lipids have a point where mechanical loads can disintegrate them, as well as a point at which they are able to resist disintegration. Prof. Gefen is now trying to determine the specific load magnitudes and frequencies for fat cells, perhaps using ultrasound at a supersonic frequency to vibrate the tissue.

Not all infomercials are light-weight

Those fat-busting "ab vibrators" that you can see on infomercials are on the right track, says Prof. Gefen, but the magnitude of mechanical loads and the frequency of their application need to be scientifically determined. Such information could be crucial to the future of our health, he says, noting that diabetes and obesity rates are rising. "Any treatment that would be effective in fighting obesity would also apply immediately to diabetes," he explains.

The next step for Prof. Gefen and his fellow researchers is to pin down the mathematical equations that allow for the dissolving of lipid droplets, then predict what a fat cell will do under certain levels of force. This will lead to better information on how to use mechanical loads to control the production of fat by fat cells — whether this means applying a certain frequency of ultrasonic vibration, or simply spending more time in the gym.

George Hunka | EurekAlert!
Further information:
http://www.aftau.org

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>