The circadian clock, a 24-hour biological cycle governing everything from seasonal flowering to hormone secretion, has been the focus of intense attention in plant science research for its wide-reaching implications to growth and development.
At the heart of this clock is a feedback loop of gene expression known as the ‘central oscillator’, whose interaction is thought to regulate biological rhythms governing various physiological processes.
With their finding, the researchers have clarified the way in which this oscillator adjusts its activity throughout the day. They show that the three proteins studied, the Pseudo-Response Regulators PRR5, PRR7 and PRR9, associate with promoter regions of the genes CCA1 and LHY to repress transcription of these genes at different times. Collectively, this sequential repression shapes the clock’s activity over the 16-hour period from day to night.
An essential component of the central oscillator, this mechanism of gene repression fills a crucial gap in our understanding of circadian clock function in plants. Artificial manipulation of the three proteins enables control over time-specific components of the clock system connected to properties such as plant size and stress tolerance, with significant potential benefits to agriculture.For more information, please contact:
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