Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Proteins used to map the aging process

20.06.2011
Loss of muscle mass is not only associated with disease, such as HIV and cancer, but also with the normal aging process. Anabolic steroids are sometimes used to reverse loss of lean muscle tissue but they can have unwanted side effects. New research, published in BioMed Central's open access journal Immunity and Aging, shows that nine proteins, isolated from blood, alter with age and that the profile of some of these proteins can be reversed by testosterone treatment.

In a combined study, researchers from Boston University School of Medicine and University of Texas Medical Branch compared protein levels in serum samples from two groups of healthy men - young men aged 18-35 and older men aged 60-75. Seven proteins, which were either growth factors (IGF-1, IL-7, IL-12p40, PDGFâ), or were involved in immune response (ENA78, MIP-1â, IP-10), and pro-collagen (PIIINP) were all reduced in older men. In contrast the monokine MIG, also involved in immune activity, was elevated.

Testosterone treatment increased lean muscle mass, and levels of the appetite suppressing hormone leptin, for both groups of men. Testosterone also increased levels of PIIINP and IGF-1 in young men and the researchers saw a similar increase in a small group of older men.

Dr Monty Montano said, "The blood proteins we found that altered with healthy aging also have links to maintenance of muscle, such as IGF-1 and pro-collagen, or are involved in regulation of the immune system, possibly reducing T-cell and neutrophil responses with age. Additionally all of the proteins we found are involved with the signaling pathways controlled by AKT, NFêâ and TGFâ which are known to be associated with aging."

Dr Montano continued, "It is no simple matter to find a one size fits all test for aging – our results suggest that there is a difference in response to anabolic steroids between young and older men, despite both groups increasing in muscle mass. It seems that testosterone replacement does not necessarily mean a restoration of full testosterone functionality for the older man."

Notes to Editors

1. Identification of serum biomarkers for aging and anabolic response
Camellia Banerjee, Jagadish Ulloor, Edgar L Dillon, Qusai Dahodwala, Brittani Franklin, Paola Sebastiani, Melinda Sheffield-Moore, Randall J Urban, Shalender Bhasin and Monty Montano

Immunity & Ageing (in press)

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication.

2. Immunity & Ageing is an Open Access, peer-reviewed, online journal that considers manuscripts on all aspects of ageing examined from an immunological point of view.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

Dr. Hilary Glover | EurekAlert!
Further information:
http://www.biomedcentral.com

Further reports about: BioMed IGF-1 Medicine PIIINP Protein STM ageing blood protein muscle mass signaling pathway

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>