Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein signal is crucial for accurate control of insect size

07.05.2012
Two independent groups of researchers have identified a hormone that is responsible for keeping the growth and development of insects on track.

The results, which are reported in the journal Science, suggest that Dilp8 provides an important signal to slow body growth and delay insect development. This braking effect is an essential part of normal development since it allows sufficient time for tissues to form and the correct body size, proportions and symmetry to be achieved.


This image shows the left-right asymmetry of an adult fly deficient in dilp8. Credit: Maria Dominguez, Instituto de Neurociencias, Alicante

"The important question about the control of animal size is knowing when to stop," said EMBO Member Maria Dominguez, lead author of one of the papers and Professor at the Institute of Neurosciences in Alicante, Spain. "To achieve the required precision in the control of growth, organs within the body of an insect must be capable of sensing their own size and communicating their dimensions to other organs in the body and to the endocrine system." She added: "Our work with Drosophila suggests that growing organs and tissues produce a secreted peptide known as Dilp8. This hormone coordinates the growth rate of different organs in the body and is capable of delaying important developmental steps such as metamorphosis. In healthy flies, this additional time is essential to ensure that functional tissues are established and for organs to reach normal size. It also ensures that organs maintain perfect bilateral symmetry."

Dominguez and collaborators examined tumours in the eye discs of Drosophila, parts of the insect body that go on to generate fully formed eyes in mature adult flies. Developing flies often adjust growth and the timing of metamorphosis to compensate for the disturbance induced by tumours or injury. The researchers wanted to investigate if a shared molecular signal was responsible for these observations. "Our work identifies Dilp8 as a signal that communicates the growth status of tissues as well as local responses to recovery from injury and cancer," said Dominguez.

EMBO Member Pierre Léopold and collaborators from the Institute of Biology Valrose at the University of Nice, France, identified the same protein using a different experimental approach. "We used a genome-wide RNA interference approach to look for Drosophila gene candidates that might be involved in coupling growth with the timing of development. Out of 11,000 genes that we tested in our genetic screen, only one was able, upon silencing, to rescue the delay in development induced by conditions that perturb tissue growth. This candidate gene corresponded to dilp8, which is exactly same gene identified by Dominguez and collaborators."

The expression of the dilp8 gene reduces tissue growth, which suggests that in addition to its role in preventing the hormonal induction of metamorphosis, dilp8 could act by slowing the growth of healthy tissues to stay synchronized with slow-growing tissue.

Until now, little information at the molecular level has been available about how organ growth is monitored and coordinated with the timing of development in insects and other complex organisms. Dilp8 appears to be part of the molecular machinery that helps tissues to grow and develop at the right pace.

Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation

Andres Garelli, Alisson M. Gontijo, Veronica Miguela, Esther Caparros, Maria Dominguez

Read the paper:
Science 4 May 2012: Vol. 336 no. 6081 pp. 579-582.
doi: 10.1126/science.1216735
Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing

Julien Colombani, Ditte S. Andersen, Pierre Léopold

Read the paper:
Science 4 May 2012: Vol. 336 no. 6081 pp. 582-585
doi: 10.1126/science.1216689
About EMBO
EMBO stands for excellence in the life sciences. The organization enables the best science by supporting talented researchers, stimulating scientific exchange and advancing policies for a world-class European research environment.

EMBO is an organization of 1500 leading life scientist members that fosters new generations of researchers to produce world-class scientific results. EMBO helps young scientists to advance their research, promote their international reputations and ensure their mobility. Courses, workshops, conferences and scientific journals disseminate the latest research and offer training in cutting-edge techniques to maintain high standards of excellence in research practice. EMBO helps to shape science and research policy by seeking input and feedback from our community and by following closely the trends in science in Europe. For more information: www.embo.org

Barry Whyte | EurekAlert!
Further information:
http://www.embo.org

More articles from Life Sciences:

nachricht Navigational view of the brain thanks to powerful X-rays
18.10.2017 | Georgia Institute of Technology

nachricht Separating methane and CO2 will become more efficient
18.10.2017 | KU Leuven

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>