The STK25 protein contributes to cell growth. Researchers at Sahlgrenska Academy, University of Gothenburg, Sweden, have discovered that the protein also affects metabolism, demonstrating that elevated levels accelerate the progress of diabetes in mice.
Researchers at Sahlgrenska Academy, University of Gothenburg have discovered a protein that may open the door to a new method of treating type 2 diabetes and other diseases caused by metabolic disorders.
Current methods not effective
Emmelie Cansby’s doctoral thesis has shown that the reduction of STK25 protein in cell cultures improves metabolism. The studies also found that mice that have elevated STK25 levels and are fed a high-fat diet are more likely to develop symptoms of diabetes.
”Current methods for treating diabetes are not effective enough,” Emmelie Cansby says. “Furthermore, they have various adverse effects, including hypoglycemia, weight gain, edema and gastrointestinal problems. New, supplementary drugs for type 2 diabetes are badly needed.”
Her thesis concludes that the STK25 protein offers the potential for an entirely new way of treating diabetes.
“Future treatment of diabetes and other metabolic disorders will hopefully include drugs that inhibit the action of STK25,” she says.
Emmelie Cansby will present her thesis, Regulation of metabolism and inflammation by two protein kinases – AMPK and STK25, on September 5.
Link to thesis: http://hdl.handle.net/2077/35938
Emmelie Cansby, Doctoral Student, Sahlgrenska Academy, University of Gothenburg
Supervisor Margit Mahlapuu, Associate Professor, +46 706 310109, email@example.com
Henrik Axlid | idw - Informationsdienst Wissenschaft
New Model of T Cell Activation
27.05.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau
Fungi – a promising source of chemical diversity
27.05.2016 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut (HKI)
A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.
The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene
In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...
24.05.2016 | Event News
20.05.2016 | Event News
19.05.2016 | Event News
27.05.2016 | Awards Funding
27.05.2016 | Life Sciences
27.05.2016 | Life Sciences