Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein Identified that Plays Role in Blood Flow

22.09.2008
MU researchers use microscopic technology to get closer to understanding vascular diseases

For years, researchers have known that high blood pressure causes blood vessels to contract and low blood pressure causes blood vessels to relax. Until recently, however, researchers did not have the tools to determine the exact proteins responsible for this phenomenon.

Now, using atomic force microscopy - a microscope with very high resolution - and isolating blood vessels outside the body, University of Missouri researchers have identified a protein that plays an important role in the control of tissue blood flow and vascular resistance. This new knowledge brings researchers one step closer to understanding vascular diseases, such as high blood pressure, diabetes and other vascular problems.

“This study provides new insights that clarify the role of specific proteins and the vascular smooth muscle cells that control the mechanical activity of blood vessels,” said Gerald Meininger, professor and director of MU’s Dalton Cardiovascular Research Center. “We have identified an important receptor that is responsible for the ability of small arteries in the body. This research provides new clues for the cause of vascular diseases, such as high blood pressure and diabetes and may be used in the future as a possible therapeutic target.”

The researchers isolated blood vessels from the body and used atomic force microscopy to apply a controlled force to particular proteins located on the surface of smooth muscle cells from the blood vessel wall. When force was applied to the proteins, the smooth muscle cells reacted, and constricted or contracted depending on the proteins that were targeted. Testing several proteins, researchers were able to pinpoint which proteins played a role in the mechanics of blood vessels.

In 90 to 95 percent of high blood pressure cases the cause is unknown, according to the American Heart Association. Understanding the role of these proteins in controlling blood vessel function will eventually lead researchers to better answers for treating and preventing vascular disease, Meininger said.

The study “Extracellular matrix-specific focal adhesions in vascular smooth muscle produce mechanically active adhesion sties,” was published in the American Journal of Physiology Cell Physiology. It was co-authored by Meininger; Zhe Sun, assistant research professor in the Dalton Cardiovascular Research Center; Luis Martinez-Lemus, assistant professor in the MU School of Medicine and investigator in the center; and Michael Hill, professor in the school and investigator in the center.

Kelsey Jackson | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Life Sciences:

nachricht Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>