The study, released today in Nature Cell Biology, is the first to specifically pinpoint a protein responsible for promoting cell repair.
Led by Jianjie Ma, PhD, professor of physiology and biophysics, the discovery has the potential to be used as a therapeutic mechanism to repair tissue in humans, transforming treatment for patients who suffer from severe complications of disease and aging. This work was performed in collaboration with Professor Hiroshi Takeshima at Kyoto University, Japan.
“Membrane repair and remodeling is an essential process that maintains cell integrity and mediates efficient cellular function,” said Dr. Ma. “Our research shows that the protein MG53 initiates the repair mechanism in damaged tissue. Through further study, we hope to determine if MG53 can be used as a treatment in repairing human tissue that is damaged by common health conditions, including cardiovascular disease and aging.”
According to Dr. Ma, human cells are continuously injured and naturally repaired through the life span, such as micro tears caused as muscles contract within the body during normal everyday activities. However, diseases such as diabetes, cardiovascular disorders, muscular dystrophy, and even aging compromise the method in which the body repairs its own tissues, resulting in severe damage. The identification of MG53 provides hope that scientists can create therapies to treat or even prevent this damage. Through further research, Dr. Ma will study the potential for creating therapies for burn treatment, repairing sports injuries and peripheral wounds resulting from diabetes.
The research was supported by grants from the National Institutes of Health, the Ministry of Education, Science, Sports and Culture of Japan and the American Heart Association.UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL
As one of the eight schools of the University of Medicine and Dentistry of New Jersey with 2,500 full-time and volunteer faculty, Robert Wood Johnson Medical School encompasses 22 basic science and clinical departments and hosts centers and institutes including The Cancer Institute of New Jersey, the Child Health Institute of New Jersey, the Center for Advanced Biotechnology and Medicine, the Environmental and Occupational Health Sciences Institute, and the Stem Cell Institute of New Jersey. The medical school maintains educational programs at the undergraduate, graduate and postgraduate levels for more than 1,500 students on its campuses in New Brunswick, Piscataway, and Camden, and provides continuing education courses for health care professionals and community education programs.
Jennifer Forbes | Newswise Science News
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine