Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prostate cancer biomarker may predict patient outcomes

06.12.2013
Researchers at Vanderbilt University Medical Center and the University of Alberta in Canada have identified a biomarker for a cellular switch that accurately predicts which prostate cancer patients are likely to have their cancer recur or spread.

The study, posted online recently in advance of publication in Cancer Research, was led by co-investigators Andries Zijlstra, Ph.D., assistant professor of Pathology, Microbiology and Immunology and Cancer Biology at Vanderbilt, and John Lewis, Ph.D., associate professor of Oncology and Frank and Carla Sojonky Chair in Prostate Cancer Research, University of Alberta.

Prostate cancer is the second leading cause of cancer-related deaths among men in North America.

While some prostate cancer spreads slowly and does not lead to serious symptoms, in other patients the cancer metastasizes to other parts of the body and proves fatal. Cancer researchers have been searching for biomarkers that indicate which patients should be treated aggressively and which patients can be followed through active surveillance.

Zijlstra and his colleagues have been investigating a protein called CD151 that facilitates the migration of cancer cells. In prostate cancer cell lines, they discovered that CD151 is free from its normal adhesion partner (integrin) — another protein that allows a cell to stick to the surrounding tissue. This form of CD151 called "CD151free" proved to be functionally important in cancer.

"It was a big surprise that some of this CD151 protein was now free of that partner and it turns out that it only occurs when a cancer is formed," said Zijlstra. "What's so novel about this discovery is we're not talking about changing protein expression, which is what we traditionally see. We're talking about a protein that changes its molecular state and detection of that molecular state is an indication of disease progression."

In collaboration with Lewis and colleagues in Alberta, the group looked at tissue samples from 137 patients treated for prostate cancer in Canada over the past 12 years.

The team determined that if patients tested positive for CD151free their cancer recurred and spread earlier than patients without any detectable CD151free.

"Patients who tested positive for the biomarker developed metastasis an average of 10 years earlier than those who tested negative," said Lewis.

Preliminary work in other solid tumors besides prostate cancer suggests that this may be a universal mechanism important for cancer progression.

"It is increasingly clear that a molecular switch in cell migration corresponds to patient outcome in solid tumors," said Zijlstra. "Consequently, the detection of that switch can assist in determining whether a patient is going to develop aggressive cancer or if the disease will remain benign. That information ultimately determines the type of care given to a cancer patient."

Lewis and Zijlstra said the integrated collaboration among basic scientists, physicians and bioinformatics/biostatisticians led to these results which should be useful for patient management. The group is working on development of an antibody test for use in the clinic.

The study was supported by funding from the National Institutes of Health (CA143081 and CA120711), Motorcycle Ride for Dad, and the Canadian Cancer Society Research Institute (Grant 700537).

Other investigators involved in the research include lead author Trenis Palmer, Ph.D., Katie Hebron, B.Sc., Celestial Jones-Paris, B.Sc., Shanna Arnold, Ph.D., Giovanna Giannico, M.D., Tatiana Ketova, Ph.D., Vanderbilt, Catalina Vasquez, M.Sc., Andrew Williams, M.D., University of Alberta, Carlos Martinez, M.D., Susanne Chan, M.D., Venu Chalasani, M.D., Joseph Chin, M.D., Translational Prostate Cancer Research Group, London, Ontario, Jose Gomez-Lemus, M.D., University of Western Ontario.

Dagny Stuart | EurekAlert!
Further information:
http://www.vanderbilt.edu

Further reports about: Cancer Vanderbilt disease progression prostate cancer solid tumors

More articles from Life Sciences:

nachricht Glycosylation: Mapping Uncharted Territory
21.09.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

nachricht Molecular Force Sensors
20.09.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Glycosylation: Mapping Uncharted Territory

21.09.2017 | Life Sciences

Highly precise wiring in the Cerebral Cortex

21.09.2017 | Health and Medicine

Did marine sponges trigger the ‘Cambrian explosion’ through ‘ecosystem engineering’?

21.09.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>