Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Promising discovery in the fight against antibiotic-resistant bacteria

23.05.2014

Researchers at the University of British Columbia have identified a small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics.

"Currently there is a severe problem with antibiotic-resistant organisms," says Bob Hancock, a professor in UBC's Dept. of Microbiology and Immunology and lead author of the study published today in PLOS Pathogens.

"Our entire arsenal of antibiotics is gradually losing effectiveness."

Many bacteria that grow on skin, lung, heart and other human tissue surfaces form biofilms, highly structured communities of bacteria that are responsible for two-thirds of all human infections.

There are currently no approved treatments for biofilm infections and bacteria in biofilms are considerably more resistant to standard antibiotics.

Hancock and his colleagues found that the peptide known as 1018-- consisting of just 12 amino acids, the building blocks of protein--destroyed biofilms and prevented them from forming.

Bacteria are generally separated into two classes, Gram-positives and Gram-negatives, and the differences in their cell wall structures make them susceptible to different antibiotics. 1018 worked on both classes of bacteria as well as several major antibiotic-resistant pathogens, including Pseudomonas aeruginosa, E. coli and MRSA.

"Antibiotics are the most successful medicine on the planet. The lack of effective antibiotics would lead to profound difficulties with major surgeries, some chemotherapy treatments, transplants, and even minor injuries," says Hancock. "Our strategy represents a significant advance in the search for new agents that specifically target bacterial biofilms."

Heather Amos | Eurek Alert!
Further information:
http://www.ubc.ca

Further reports about: Immunology Promising Pseudomonas aeruginosa antibiotics bacteria effectiveness infections surfaces

More articles from Life Sciences:

nachricht Faster fish thanks to nMLF neurons
25.07.2014 | Max Planck Institute of Neurobiology, Martinsried

nachricht A glimpse into the genetic basis of schizophrenia
25.07.2014 | Max Planck Institute of Psychiatry, München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

First International Conference on Consumer Research | ICCR 2014: Early bird deadline July 31, 2014

08.07.2014 | Event News

 
Latest News

Parched West is using up underground water, UCI, NASA find

25.07.2014 | Earth Sciences

ORNL study reveals new characteristics of complex oxide surfaces

25.07.2014 | Materials Sciences

New mass map of a distant galaxy cluster is the most precise yet

25.07.2014 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>