Colitis is a disease in which the inner tissue of the colon, the mucosa, becomes inflamed and damaged and can result in painful sores. Ulcerative colitis and Crohn’s disease are the two major types of Inflammatory Bowel Disease (IBD). It is not yet known what causes the diseases, but both are believed to be the result of altered intestinal immune responses in genetically predisposed individuals.
A probiotic is a live microorganism -- in this case, a bacterium -- that benefits its host. B. polyfermenticus is available in Japan and Korea to treat intestinal disorders such as diarrhea and constipation. The bacterium is quite hardy and can survive the hostile environment of the stomach and intestine.
The study not only provided evidence of B. polyfermenticus’ usefulness in treating colitis during the non-inflammatory phase, but also showed that it works by healing intestinal wounds more quickly by encouraging the growth of new blood vessels, a process known as angiogenesis.
The study, “The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8,” appears in the online edition of the American Journal of Physiology – Gastrointestinal and Liver Physiology. The authors are Eunok Im, Yoon Jeong Choi, Cho Hee Kim, Charalabos Pothoulakis and Sang Hoon Rhee, all of the David Geffen School of Medicine, University of California at Los Angeles and Claudio Fiocchi, of the Cleveland Clinic Foundation Lerner Research Institute, Cleveland. The American Physiological Society (www.the-aps.org) published the research.Study with live mice and human cells
The test tube study allowed an in-depth look at what happens at the cellular level when human intestinal microvascular endothelial cells are exposed to B. polyfermenticus. This phase found that the probiotic treatment encouraged several steps that are part of the angiogenic process, including the migration of cells and the formation of new blood vessels.
The test tube studies also uncovered how this happens. The researchers found that B. polyfermenticus increases the production of Interleukin-8 (IL-8), a substance that enhances angiogenesis. The study also found that IL-8’s receptor, CXCR2, and a cellular pathway, known as NF-êB, play a critical role in the angiogenic process.Role of Angiogenesis
“Our findings suggest that the probiotic bacterium, when applied at the healing phase of experimental inflammatory bowel disease, increased angiogenesis and thus enhanced wound healing and facilitated recovery of mice from colitis,” Dr. Rhee said. “Angiogenesis is essential for both inflammation and wound healing, and therefore it is important to apply angiogenic therapy when there is a requirement for wound healing and anti-angiogenic therapy when there is active inflammation,” he said. Further studies are necessary before it is known whether these results can be applied to humans.
Editor’s Notes: To arrange an interview with Dr. Rhee, please contact Christine Guilfoy (301) 634-7253 or at email@example.com.
Funding: Binex Co. Ltd., Flight Attendant Medical Research Institute and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.
Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society (APS) has been an integral part of this scientific discovery process since it was established in 1887.
Christine Guilfoy | Newswise Science News
The world's tiniest first responders
21.06.2018 | University of Southern California
A new toxin in Cholera bacteria discovered by scientists in Umeå
21.06.2018 | Schwedischer Forschungsrat - The Swedish Research Council
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
21.06.2018 | Earth Sciences
21.06.2018 | Life Sciences
21.06.2018 | Earth Sciences