Colitis is a disease in which the inner tissue of the colon, the mucosa, becomes inflamed and damaged and can result in painful sores. Ulcerative colitis and Crohn’s disease are the two major types of Inflammatory Bowel Disease (IBD). It is not yet known what causes the diseases, but both are believed to be the result of altered intestinal immune responses in genetically predisposed individuals.
A probiotic is a live microorganism -- in this case, a bacterium -- that benefits its host. B. polyfermenticus is available in Japan and Korea to treat intestinal disorders such as diarrhea and constipation. The bacterium is quite hardy and can survive the hostile environment of the stomach and intestine.
The study not only provided evidence of B. polyfermenticus’ usefulness in treating colitis during the non-inflammatory phase, but also showed that it works by healing intestinal wounds more quickly by encouraging the growth of new blood vessels, a process known as angiogenesis.
The study, “The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8,” appears in the online edition of the American Journal of Physiology – Gastrointestinal and Liver Physiology. The authors are Eunok Im, Yoon Jeong Choi, Cho Hee Kim, Charalabos Pothoulakis and Sang Hoon Rhee, all of the David Geffen School of Medicine, University of California at Los Angeles and Claudio Fiocchi, of the Cleveland Clinic Foundation Lerner Research Institute, Cleveland. The American Physiological Society (www.the-aps.org) published the research.Study with live mice and human cells
The test tube study allowed an in-depth look at what happens at the cellular level when human intestinal microvascular endothelial cells are exposed to B. polyfermenticus. This phase found that the probiotic treatment encouraged several steps that are part of the angiogenic process, including the migration of cells and the formation of new blood vessels.
The test tube studies also uncovered how this happens. The researchers found that B. polyfermenticus increases the production of Interleukin-8 (IL-8), a substance that enhances angiogenesis. The study also found that IL-8’s receptor, CXCR2, and a cellular pathway, known as NF-êB, play a critical role in the angiogenic process.Role of Angiogenesis
“Our findings suggest that the probiotic bacterium, when applied at the healing phase of experimental inflammatory bowel disease, increased angiogenesis and thus enhanced wound healing and facilitated recovery of mice from colitis,” Dr. Rhee said. “Angiogenesis is essential for both inflammation and wound healing, and therefore it is important to apply angiogenic therapy when there is a requirement for wound healing and anti-angiogenic therapy when there is active inflammation,” he said. Further studies are necessary before it is known whether these results can be applied to humans.
Editor’s Notes: To arrange an interview with Dr. Rhee, please contact Christine Guilfoy (301) 634-7253 or at email@example.com.
Funding: Binex Co. Ltd., Flight Attendant Medical Research Institute and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.
Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society (APS) has been an integral part of this scientific discovery process since it was established in 1887.
Christine Guilfoy | Newswise Science News
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences