Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prevent influenza virus infections systematically

29.01.2013
ViroSign - an interdisciplinary BMBF funded network

Viral epidemics and pandemics remain a constant threat for human population. This impact was particularly demonstrated by the recent transmission and explosive worldwide spread of a swine origin influenza virus among humans and the ongoing highly lethal infections with avian subtype strains.


Influenza viruses close to a host cell

Influenza virus infections are a major cause for respiratory disease, which affect all age groups and can occur repeatedly in any particular individual.

The newly established research network “ViroSign – Systems Virology of Influenza – Molecular Signature of permissive Virus Infection” is an interdisciplinary project that combines different aspects of systems biology ranging from the global system-wide analysis of cellular proteins to high-resolution microscopy of single viruses and mathematical modeling.

The aim is to unravel the interaction network of each viral component as well as the signature of all cellular proteins (proteome) produced by the host-cell as a response to the pathogen. Experiments and theory will be directed towards the identification of cellular interactors and viral proteins responsible for a specific host cell response. Bioinformatics will build upon these results and integrate previous data on studies as the identification of host cell factors required for virus replication. “This identification will allow the construction of a systemic model of influenza virus host interaction and will be useful for making predictions for the specific design and application of drugs and inhibitors to prevent infection”, explains Andreas Herrmann, Professor at the Department of Molecular Biophysics at Humboldt-Universität zu Berlin and ViroSign Co-ordinator.

The project is funded with 1,94 Mill. € by the Federal Ministry of Education and Research in the frame of the program e:Bio. Teams with complementary expertise of different institution in the Berlin region are involved: Integrative Research Institute (IRI) for the Life Sciences at Humboldt-Universität zu Berlin (Prof. Dr. Dr. h.c. Edda Klipp, Prof. Dr. Andreas Herrmann (co-ordinator)), Max-Planck-Institute for Infection Biology (Prof. Dr. Thomas Meyer), Robert-Koch-Institute Berlin (PD Dr. Thorsten Wolff) and Max-Delbrück-Center for Molecular Medicine (Prof. Dr. Matthias Selbach).

Contact
Prof. Dr. Andreas Herrmann
Humboldt-Universität zu Berlin
Department of Biology
Phone: +49 30 2093-8830
Andreas.Herrmann@rz.hu-berlin.de

Constanze Haase | idw
Further information:
http://www.hu-berlin.de

More articles from Life Sciences:

nachricht High-Speed Locomotion Neurons Found in the Brainstem
24.10.2017 | Universität Basel

nachricht Antibiotic resistance: a strain of multidrug-resistant Escherichia coli is on the rise
24.10.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Antibiotic resistance: a strain of multidrug-resistant Escherichia coli is on the rise

24.10.2017 | Life Sciences

High-Speed Locomotion Neurons Found in the Brainstem

24.10.2017 | Life Sciences

How effective are bonding agents? Fraunhofer uses liquid chromatography for characterization

24.10.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>