Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Preparation of anti-tumor nanoparticles using tiger milk mushroom

07.08.2012
Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from HKPolyU uses tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

Cancer is a word dreaded by many. Many cancers are deadly and difficult to treat while conventional remedies such as chemotherapy often cause physical and emotional sides effects, giving struggling patients more harm just as the cancer. What if cancer-killing drugs can become more natural and in harmony with our body?


A polysaccharide-protein complex was found in Tiger Milk mushrooms from Africa, which can turn selenium into new cancer treatment

Copyright : Hong Kong Polytechnic University

Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from PolyU’s Department of Applied Biology and Chemical Technology using tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

A natural compound found in mushrooms may hold the key to a new class of cancer drugs. In Tiger Milk mushrooms from Africa, Dr Wong Ka-hing, Associate Director of the Food Safety and Technology Research Centre, has discovered a polysaccharide-protein complex (PSP) which can turn selenium, a common nutrient, into new cancer therapy to benefit millions of breast cancer patients around the world.

Selenium is a trace mineral essential for good health. Health benefits include boosting immune systems against viral infections. Staple foods and vegetables in our diet such as rice, wheat, potatoes, broccolis and onions are great sources of antioxidant. In nano-size, selenium was found to have potent anti-cancer effect in the laboratory. However, efficacy diminished as the nanoparticles fell back into bigger aggregates which suppressed the up-take into cancer cells. Finding new ways or compounds to halt the rebinding process is harder than it seems. Literally, it is quite like searching for a needle in a haystack.

The use of mushroom PSP as stabilizing force is a significant breakthrough. Combined with cutting-edge nanotechnology, Dr Wong and his team successfully made selenium nanoparticles to destroy breast cancer cells. “Lab-test results were exciting. Our selenium nanoparticles were found to have remarkable inhibition effect on the growth of human breast cancer cells by triggering the cells into self-destruction. The next stage will be tests on animals,” Dr Wong said.

The research is still in a very early phase. But if successful, it could lead to a new drug much less toxic and more reliable, capable of killing cancer cells while leaving healthy tissues unharmed, which could mean fewer agonizing side-effects, greater comfort and better chances of recovery. Dr Wong also planned on developing a dietary supplement as auxiliary cancer treatments.

Scientists around the world have been looking into the therapeutic value of produces such as fish oil, broccoli, cauliflower, cabbage, and green tea. For safe human consumption, a natural ingredient must be effective against cancer in low concentration. Dr Wong’s work has advanced medicine with a working tool for boosting the effectiveness of natural cancer killing compounds.

“Mushroom PSP has striking effects on controlling selenium nanoparticles,” Dr. Wong added, “and a better understanding of this mechanism may help us find the next suitable compounds and make better nano-medicines for a whole host of cancers.” Tiger Milk, similar to Chinese mushrooms we have in dishes and soups mushroom, is a common foodstuff in Africa, and the groundbreaking biomedical research opens door to making cancer drug from 100% natural ingredients. The drug development process is equally natural and green because all it takes are room temperature and water, which is little waste and without much power consumption.

Holding new promise for beating cancer, this research has won Dr Wong the Young Investigator Award at the 2011 International Conference of Food Factors and the Gold Medal in 40th International Exhibition of Inventions of Geneva. These prestigious awards were at the same time an endorsement to the long-running commitment from the University to the discovery and development of ingredients for the betterment of the community.

Wilfred Lai | Research asia research news
Further information:
http://www.pdo.polyu.edu.hk/en/technology_frontier.asp?ID=92
http://www.researchsea.com

More articles from Life Sciences:

nachricht Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University

nachricht Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>