Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Predicting Cell Behaviour with a Mathematical Model

19.04.2016

Heidelberg physicists develop new software for the life sciences

Scientists from Heidelberg University have developed a novel mathematical model to explore cellular processes: with the corresponding software, they now are able to simulate how large collections of cells behave on given geometrical structures.


Computer simulations show that skin cell ensembles on a micropatterned substrate simulating a wound can bridge gaps of up to about 200 micrometres.

Philipp Albert

The software supports the evaluation of microscope-based observations of cell behaviour on micropatterned substrates. One example is a model for wound healing in which skin cells are required to fill a gap. Other areas of application lie in high throughput screening for medicine when a decision needs to be taken automatically on whether a certain active substance changes cell behaviour.

Prof. Dr. Ulrich Schwarz and Dr. Philipp Albert work both at the Institute for Theoretical Physics and at the Bioquant Centre of Heidelberg University. Their findings were recently published in “PLOS Computational Biology”.

One of the most important foundations of the modern Life Sciences is being able to cultivate cells outside the body and to observe them with optical microscopes. In this way, cellular processes can be analysed in much more quantitative detail than in the body.

However, at the same time a problem arises. “Anyone who has ever observed biological cells under a microscope knows how unpredictable their behaviour can be. When they are on a traditional culture dish they lack ‘orientation’, unlike in their natural environment in the body.

That is why, regarding certain research issues, it is difficult to derive any regularities from their shape and movement,” explains Prof. Schwarz. In order to learn more about the natural behaviour of cells, the researchers therefore resort to methods from materials science. The substrate for microscopic study is structured in such a way that it normalises cell behaviour.

The Heidelberg physicists explain that with certain printing techniques, proteins are deposited on the substrate in geometrically well-defined areas. The cell behaviour can then be observed and evaluated with the usual microscopy techniques.

The group of Ulrich Schwarz aims at describing in mathematical terms the behaviour of biological cells on micropatterned substrates. Such models should make it possible to quantitatively predict cell behaviour for a wide range of experimental setups. For that purpose, Philipp Albert has developed a complicated computer programme which considers the essential properties of individual cells and their interaction. It can also predict how large collections of cells behave on the given geometric structures.

He explains: “Surprising new patterns often emerge from the interplay of several cells, such as streams, swirls and bridges. As in physical systems, e.g. fluids, the whole is here more than the sum of its parts. Our software package can calculate such behaviour very rapidly.” Dr Albert’s computer simulations show, for example, how skin cell ensembles can overcome gaps in a wound model up to about 200 micrometres.

Another promising application of these advances is investigated by Dr. Holger Erfle and his research group at the BioQuant Centre, namely high throughput screening of cells. Robot-controlled equipment is used to carry out automatic pharmacological or genetic tests with many different active substances. They are, for example, designed to identify new medications against viruses or for cancer treatment. The new software now enables the scientists to predict what geometries are best suited for a certain cell type. The software can also show the significance of changes in cell behaviour observed under the microscope.

The research projects by Prof. Schwarz, Dr. Albert and Dr. Erfle received European Union funding from 2011 to 2015 via the program “Micropattern-Enhanced High Throughput RNA Interference for Cell Screening” (MEHTRICS). Besides the BioQuant Centre, this consortium included research groups from Dresden, France, Switzerland and Lithuania. The total support for the projects amounted to EUR 4.4 million euros.

Contact:
Prof. Dr. Ulrich Schwarz
Institute for Theoretical Physics
Phone +49 6221 54-9431
schwarz@thphys.uni-heidelberg.de

Communications and Marketing
Press Office
Phone +49 6221 54-2311
presse@rektorat.uni-heidelberg.de

Marietta Fuhrmann-Koch | idw - Informationsdienst Wissenschaft
Further information:
http://www.uni-heidelberg.de

Further reports about: biological cells cellular processes substrates

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>