Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Self-powered, Blood-activated Sensor Detects Pancreatitis Quickly and Cheaply

A new low cost test for acute pancreatitis that gets results much faster than existing tests has been developed by scientists at The University of Texas at Austin.

The sensor, which could be produced for as little as a dollar, is built with a 12-cent LED light, aluminum foil, gelatin, milk protein and a few other cheap, easily obtainable materials.

The sensor could help prevent damage from acute pancreatitis, which is a sudden inflammation of the pancreas that can lead to severe stomach pain, nausea, fever, shock and in some cases, death.

“We’ve turned Reynold’s Wrap, JELL-O and milk into a way to look for organ failure,” says Brian Zaccheo, a graduate student in the lab of Richard Crooks, professor of chemistry and biochemistry.

The sensor, which is about the size of a matchbox, relies on a simple two-step process to diagnose the disease.

In step one, a bit of blood extract is dropped onto a layer of gelatin and milk protein. If there are high levels of trypsin, an enzyme that is overabundant in the blood of patients with acute pancreatitis, the trypsin will break down the gelatin in much the same way it breaks down proteins in the stomach.

In step two, a drop of sodium hydroxide (lye) is added. If the trypsin levels were high enough to break down that first barrier, the sodium hydroxide can trickle down to the second barrier, a strip of Reynold’s wrap, and go to work dissolving it.

The foil corrodes, and with both barriers now permeable, a circuit is able to form between a magnesium anode and an iron salt at the cathode. Enough current is generated to light up a red LED. If the LED lights up within an hour, acute pancreatitis is diagnosed.

“In essence, the device is a battery having a trypsin-selective switch that closes the circuit between the anode and cathode,” write Zaccheo and Crooks in a paper recently published in Analytical Chemistry.

Zaccheo and Crooks, who have a provisional patent, can envision a number of potential uses for the sensor. It might help providers in the developing world who don’t have the resources to do the more complex tests for pancreatitis. It could be of use in situations where batteries are in short supply, such as after a natural disaster or in remote locations. And because of the speed of the sensor, it could be an excellent first-line measure even in well-stocked hospitals.

For Zaccheo, the most appealing aspect of the project isn’t so much the specific sensor. It is the idea we might be able to save time, money and even lives by adopting this kind of low-tech approach.

“I want to develop biosensors that are easy to use but give a high level of sensitivity,” he says. “All you need for this, for instance, is to know how to use a dropper and a timer.”

Brian Zaccheo | EurekAlert!
Further information:

Further reports about: Blood-activated Cheaply Crooks LED Self-powered Sensor Zaccheo pancreatitis

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>