Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Potential biologic markers of cholangiocarcinoma

Dr. Hong-Yang Wang and his colleagues confirmed that reduced or absent expressions of E-cadherin and P120 were shown to be associated with the tumor histological grade. And their expression significantly associated with tumor pTNM stage, intrahepatic metastasis and patients' survival. Therefore, both of them could serve as potential diagnostic and prognostic markers of ICCs.

This study, is described in a research published on 21 June 2008, in the World Journal of Gastroenterology. Performed by a team led by Dr. HY Wang.P120-catenin is a member of the Armadillo (ARM)/ß-catenin gene familyand is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness.

A main function of P120 is to stabilize cadherins at the cell membrane by regulating cadherin turnover and degradation. In this way, P120 levels act as a set point mechanism that tunes cell-cell adhesive interactions. Several reports had suggested that abnormal expression of P120 occurred in various of tumors, but no one navigated the role of P120 in the progress and development of ICCs.

An immunohistochemical study for E-cadherin and P120 catenin was performed in 42 specimens of human ICCs with Dako Envision Kit. Their study suggested that reduced or absent expressions of E-cadherin and P120 were shown to be associated with the tumor histological grade. In well differentiated tumors, there were obvious and strongly staining along cell-cell boundaries, whereas in poorly differentiated tumors, immunohistostaining patterns were focally and heterogeneously distributed, with patchy or spotty features along cell-cell boundaries. Thus, the staining of E-cadheri and P120 was related with the tumor differentiation of ICC. That's to say, both E-cadherin and P120 may be regarded as tumor differentiation markers. In addition, the staining strength of this complex gradually weakened from nontumoral tissue to tumor region, suggesting that P120 may play a critic role in ICC progression.

Additionally, this study suggested that the expression of P120 and E-cadherin significantly associated with tumor pTNM stage and intrahepatic metastasis. Therefore, E-cadherin and P120 may be important meditors in tumor progression and can be considered as invasion and metastasis markers of ICC.

Lastly, they also evaluated the relationship between the expression of E-cadherin/P120 and patients' survival and found that both reduced expression of E-cadherin and P120 were significantly related with the patients' survival. However, only the abnormal expression of P120 was found to be an independent prognostic factor. Thus, P120 could be considered as a valuable biological marker at predicting on patients' prognosis in ICCs.

Reference: Zhai B, Yan HX, Liu SQ, Chen L, Wu MC, Wang HY. Reduced expression of the P120 catenin in human intrahepatic cholangiocarcinoma correlations with tumor clinicopathologic parameters and patients' survival. World J Gastroenol 2008; 14(23): 3739-3744

Correspondence to: Hong-Yang Wang, International Cooperation Laboratory On Signal Transduction, Eastern Hepatobilliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

Telephone: +86-21-25070846 Fax: +86-21-65566851

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

Lai-Fu Li | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>