This study, is described in a research published on 21 June 2008, in the World Journal of Gastroenterology. Performed by a team led by Dr. HY Wang.P120-catenin is a member of the Armadillo (ARM)/ß-catenin gene familyand is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness.
A main function of P120 is to stabilize cadherins at the cell membrane by regulating cadherin turnover and degradation. In this way, P120 levels act as a set point mechanism that tunes cell-cell adhesive interactions. Several reports had suggested that abnormal expression of P120 occurred in various of tumors, but no one navigated the role of P120 in the progress and development of ICCs.
An immunohistochemical study for E-cadherin and P120 catenin was performed in 42 specimens of human ICCs with Dako Envision Kit. Their study suggested that reduced or absent expressions of E-cadherin and P120 were shown to be associated with the tumor histological grade. In well differentiated tumors, there were obvious and strongly staining along cell-cell boundaries, whereas in poorly differentiated tumors, immunohistostaining patterns were focally and heterogeneously distributed, with patchy or spotty features along cell-cell boundaries. Thus, the staining of E-cadheri and P120 was related with the tumor differentiation of ICC. That's to say, both E-cadherin and P120 may be regarded as tumor differentiation markers. In addition, the staining strength of this complex gradually weakened from nontumoral tissue to tumor region, suggesting that P120 may play a critic role in ICC progression.
Additionally, this study suggested that the expression of P120 and E-cadherin significantly associated with tumor pTNM stage and intrahepatic metastasis. Therefore, E-cadherin and P120 may be important meditors in tumor progression and can be considered as invasion and metastasis markers of ICC.
Lastly, they also evaluated the relationship between the expression of E-cadherin/P120 and patients' survival and found that both reduced expression of E-cadherin and P120 were significantly related with the patients' survival. However, only the abnormal expression of P120 was found to be an independent prognostic factor. Thus, P120 could be considered as a valuable biological marker at predicting on patients' prognosis in ICCs.Reference: Zhai B, Yan HX, Liu SQ, Chen L, Wu MC, Wang HY. Reduced expression of the P120 catenin in human intrahepatic cholangiocarcinoma correlations with tumor clinicopathologic parameters and patients' survival. World J Gastroenol 2008; 14(23): 3739-3744
http://www.wjgnet.com/1007-9327/14/3739.aspCorrespondence to: Hong-Yang Wang, International Cooperation Laboratory On Signal Transduction, Eastern Hepatobilliary Surgery Institute, Second Military Medical University, Shanghai 200438, China. email@example.com
Telephone: +86-21-25070846 Fax: +86-21-65566851
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
Lai-Fu Li | EurekAlert!
Fingerprint' technique spots frog populations at risk from pollution
27.03.2017 | Lancaster University
Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
27.03.2017 | Earth Sciences
27.03.2017 | Life Sciences
27.03.2017 | Life Sciences