Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New potential atherosclerosis risk marker discovered

12.04.2011
How your carotid artery moves can reveal your risk of a future heart attack, and it is now possible to study this vessel aspect in more detail thanks to a new technique which could eventually be used to identify patients with suspected coronary artery disease, reveals a thesis from the University of Gothenburg, Sweden.

Atherosclerosis in the coronary arteries is associated with a risk of future heart disease, and it is therefore important to find risk markers for atherosclerotic disease.

“When the heart beats, the body's blood vessels increase in diameter, and there is also movement alongside the blood vessels, known as longitudinal displacement, or tLod,” explains researcher Sara Svedlund from the Department of Molecular and Clinical Medicine at the Sahlgrenska Academy. “It was not previously possible to tell whether this movement had any impact on health, as there was a lack of adequate measurement techniques.”

In her thesis, Svedlund investigated whether ultrasound technique could be used to study tLoD in the blood vessels in the neck. This would provide a simple and painless method of identifying patients at increased risk of coronary artery disease.

She used an advanced imaging analysis technique to study movement in the carotid artery using standard clinical ultrasound images. The method was tested on around 500 people, both patients with suspected coronary artery disease and healthy volunteers. It has also been transferred to experimental animal models for more in-depth studies in future.

Patients with reduced longitudinal displacement along the carotid artery have more extensive atherosclerosis in that artery, impaired heart function and a greater tendency to suffer from a shortage of oxygen in the heart. In a follow-up study, Svedlund has also been able to show that this new risk marker can predict the risk of future cardiovascular events.

“Today's methods look only at the thickness of the artery walls when identifying atherosclerosis. Our technique shows that longitudinal displacement in the carotid artery reflects both the degree of atherosclerosis in the artery and heart function. This new method may therefore give us additional information and enable us to predict which patients run an increased risk of future heart disease. We will follow up these interesting findings in further studies to establish the technique which potentially can be used in clinical routine in the future.”

ATHEROSCLEROSIS
Atherosclerosis is the accumulation of cholesterol in the arteries to form hard plaques, which can cause diseases such as angina, heart attacks and strokes. Atherosclerosis-related diseases cause 40-50% of all deaths in Sweden each year.
For more information, please contact:
Sara Svedlund, MD and PhD student, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, e-mail: sara.svedlund@gu.se
Journal: Clin Physiol Funct Imaging. 2011 Jan;31(1):32-8.
Authors: Sara Svedlund, Li-ming Gan.
Title: Longitudinal Wall Motion of the Common Carotid Artery Can be Assessed by Velocity Vector Ultrasound Imaging

Helena Aaberg | idw
Further information:
http://hdl.handle.net/2077/23938
http://www.gu.se

More articles from Life Sciences:

nachricht Enduring cold temperatures alters fat cell epigenetics
19.04.2018 | University of Tokyo

nachricht Full of hot air and proud of it
18.04.2018 | University of Pittsburgh

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

Im Focus: Stronger evidence for a weaker Atlantic overturning

The Atlantic overturning – one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards – is weaker today than any time before in more than 1000 years. Sea surface temperature data analysis provides new evidence that this major ocean circulation has slowed down by roughly 15 percent since the middle of the 20th century, according to a study published in the highly renowned journal Nature by an international team of scientists. Human-made climate change is a prime suspect for these worrying observations.

“We detected a specific pattern of ocean cooling south of Greenland and unusual warming off the US coast – which is highly characteristic for a slowdown of the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Improved stability of plastic light-emitting diodes

19.04.2018 | Power and Electrical Engineering

Enduring cold temperatures alters fat cell epigenetics

19.04.2018 | Life Sciences

New capabilities at NSLS-II set to advance materials science

18.04.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>