These findings, by Sérgio Dias and his team, are to appear in the new issue of the journal PLoSOne(*), and have implications for the development of new therapeutic approaches to healing damaged blood vessels and building new ones.
Working at the Centro de Investigação e Patobiologia Molecular of the Portuguese Institute of Oncology Francisco Gentil, in Lisbon, the team showed that the cells that make new blood vessels (called endothelial cells) are stimulated by an intracellular signalling pathway, mediated by the protein Notch.
The formation of new blood vessels is a crucial step in wound healing: the newly-formed vessels allow anti-inflammatory proteins to reach the wound site, improve oxygenation of the damaged tissue and carry essential nutrients for the re-structuring of the tissue, that is, the skin.
According to Francisco Caiado, a PhD student at the IGC, and first author of this study, “We knew that the endothelial cells are stimulated by cells originating in the bone-marrow, the so-called bone-marrow derived precursor cells. We have now shown that the actual stimulus happens through the Notch protein, found on the bone-marrow derived cells. Upon activation, Notch promotes the adhesion of the precursor cells to the site of the lesion, where they stimulate the endothelial cells to make new blood vessels”.
Chronic skin wounds are an increasing medical problem, since they are commonly found in diabetic patients and in those suffering from morbid obesity. Diabetic patients may develop “diabetic foot”, a condition whereby wounds do not heal leading, in the most severe cases, to amputation.
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
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