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Polysaccharides from Angelica sinensis alleviate oxidative damage to neurons


According to traditional Chinese medicine, the roles of Angelica sinensis correlate with tonifying the blood and promoting its circulation.

Recent studies have shown that extracts of Angelica sinensis have antioxidative and neuroprotective effects.

Under a laser scanning confocal microscopy, perfused microvessels were abundant after treatment with Angelica sinensis polysaccharide.

Credit: Neural Regeneration Research

However, the anti-oxidative function of Angelica sinensis polysaccharide has rarely been addressed.

In a preliminary experiment from Dr. Tao Lei and colleagues from Zhongnan Hospital of Wuhan University in China, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment.

In a rat model of local cerebral ischemia, they further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia.

Their findings, published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.


Article: " Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress," by Tao Lei1, Haifeng Li2, Zhen Fang1, Junbin Lin1, Shanshan Wang1, Lingyun Xiao2, Fan Yang2, Xin Liu2, Junjian Zhang1, Zebo Huang2, Weijing Liao1 (1 Department of Rehabilitation Medicine, Zhongnan Hospital and Cerebral Vascular Diseases Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China; 2 School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei Province, China)

Lei T, Li HF, Fang Z, Lin JB, Wang SS, Xiao LY, Yang F, Liu X, Zhang JJ, Huang ZB, Liao WJ. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress. Neural Regen Res. 2014;9(3):260-267.

Contact: Meng Zhao
Neural Regeneration Research

Meng Zhao | EurekAlert!

Further reports about: H2O2 Regeneration apoptosis cerebral damage injury ischemia neurons neuroprotective polysaccharides species

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