Jena scientists from different disciplines founded a new network in order to utilize so-called nanocontainers for applications in the biomedical field ("NanoConSens"). The research collaboration is now being funded by the State of Thuringia for the next 3 years with EUR 1.25 million within the framework of the "ProExzellenz Initiative".
"We aim at building up and optimizing various nanocontainers in such way that they - as intelligent transport vehicles - release active agents in the right dose at the right time at the right place in the human body", Prof. Dr. Ulrich S. Schubert from the University in Jena describes the direction of the project. "With that, high-impact medicine which is not blood soluble", explains the initiative's coordinator, "can be selectively transported to its destination without side effects. We are striving to enclose, for instance, antibiotics or even complex molecules like siRNA."
Such different substances require transport vehicles that are individually tailored to the special type of molecule. Moreover, they have to be provided with molecules navigating on their surface, like for example sugars or peptides. The new collaboration is, among other things, using combinations of novel concepts for building up star-shaped polymers, employing cationic polymers, varying the size of the nanocontainers and utilizing state-of-the-art methods of synthesis (like the so-called "click chemistry"). Furthermore, modified nanocontainers can be employed as sensors for the investigation of living cells - for example to determine ionic concentration, temperature or pH value.
The eight funded interdisciplinary subprojects unite partners from such disciplines as chemistry, pharmacy, medicine and biology from the Friedrich Schiller University Jena and the Leibniz Institute for Natural Product Research and Infection Biology - "Hans-Knöll-Institute" (HKI). The entire project helps strengthen the research profile of the Friedrich Schiller University Jena and its research focus on "Innovative Materials and Technologies" (www.materials.uni-jena.de).Contact:
Axel Burchardt | idw
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy