Jena scientists from different disciplines founded a new network in order to utilize so-called nanocontainers for applications in the biomedical field ("NanoConSens"). The research collaboration is now being funded by the State of Thuringia for the next 3 years with EUR 1.25 million within the framework of the "ProExzellenz Initiative".
"We aim at building up and optimizing various nanocontainers in such way that they - as intelligent transport vehicles - release active agents in the right dose at the right time at the right place in the human body", Prof. Dr. Ulrich S. Schubert from the University in Jena describes the direction of the project. "With that, high-impact medicine which is not blood soluble", explains the initiative's coordinator, "can be selectively transported to its destination without side effects. We are striving to enclose, for instance, antibiotics or even complex molecules like siRNA."
Such different substances require transport vehicles that are individually tailored to the special type of molecule. Moreover, they have to be provided with molecules navigating on their surface, like for example sugars or peptides. The new collaboration is, among other things, using combinations of novel concepts for building up star-shaped polymers, employing cationic polymers, varying the size of the nanocontainers and utilizing state-of-the-art methods of synthesis (like the so-called "click chemistry"). Furthermore, modified nanocontainers can be employed as sensors for the investigation of living cells - for example to determine ionic concentration, temperature or pH value.
The eight funded interdisciplinary subprojects unite partners from such disciplines as chemistry, pharmacy, medicine and biology from the Friedrich Schiller University Jena and the Leibniz Institute for Natural Product Research and Infection Biology - "Hans-Knöll-Institute" (HKI). The entire project helps strengthen the research profile of the Friedrich Schiller University Jena and its research focus on "Innovative Materials and Technologies" (www.materials.uni-jena.de).Contact:
Axel Burchardt | idw
Ambush in a petri dish
24.11.2017 | Friedrich-Schiller-Universität Jena
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons
The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
24.11.2017 | Physics and Astronomy
24.11.2017 | Health and Medicine
24.11.2017 | Earth Sciences