The stem cells must reside in special niches of the muscle for efficient growth and repair. The developmental biologists Dr. Dominique Bröhl and Prof. Carmen Birchmeier of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have elucidated how these stem cells colonize these niches.
In healthy mice a stem cell (red) resides in a special niche between the muscle cell and the basal lamina (green) (left) which surrounds it. If the Notch signaling pathway is mutated, the stem cell locates outside of the muscle fiber (right) and hardly contributes to muscle growth.
(Photo: Dominique Bröhl/ Copyright: MDC)
Weakened stem cells
In the present study Dr. Bröhl and Professor Birchmeier showed that mouse muscle progenitor cells lacking components of the Notch signaling pathway cannot colonize their niche. Instead the muscle progenitor cells locate in tissue between the muscle fibers. The developmental biologists view this as the cause for the weakening of the muscles. The stem cells that are “in the wrong place” are no longer as potent as they originally were and hardly contribute to muscle growth.
In addition, the Notch signaling pathway has a second function in muscle development. It prevents the differentiation of stem cells into muscle cells through suppression of the muscle developmental factor MyoD and thus ensures that there will always be a pool of stem cells for muscle repair and regeneration. In the future this work could gain in importance for research on muscle regeneration and muscle weakness.
*Colonization of the Satellite Cell Niche by Skeletal Muscle Progenitor Cells Depends on Notch Signals
Barbara Bachtler | Max-Delbrück-Centrum
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