Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Self-perpetuating signals may drive tumor cells to spread

17.07.2013
A team of international researchers from Duke-NUS Graduate Medical School Singapore and the Johns Hopkins University School of Medicine (USA) has identified a self-perpetuating signaling circuit inside connective tissue cells that allows these cells to form a front and a back and propel themselves in a particular direction over a long period of time.

This propulsion is the same movement that tumor cells use to invade healthy tissue during cancer metastasis so cracking the code to this signaling network may lead to new therapeutic strategies against cancer and other devastating diseases.

Many different types of cells in our body can crawl and migrate to distinct locations, sometimes over long distances. Immune system cells, for example, move to a wound site to kill microorganisms during an infection, and connective tissue cells (fibroblasts) move there to repair damaged areas. Cell migration is essential to a variety of biological processes, such as the development of an organism, wound healing, and immune surveillance, but also the invasion of tumor cells during cancer metastasis.

Cell migration is an extraordinarily complex process which depends on the ability of a cell to form a front and a back (called polarization) and generate force in one preferred direction. Migrating cells are able to do this spontaneously, without assistance from the environment. How they do this is a question that has kept cell biologists busy for the last three decades.

These latest results shed light on the migratory mechanism of cells. In particular, the team found that the signaling network involved has an interesting property, well known to engineers and bankers: it is self-perpetuating. A classic analogy to this type of circuit is a bank run, which occurs when a large number of customers withdraw their money from a bank due to concerns about the bank's solvency. As more people withdraw their funds, the probability of default increases, prompting more people to withdraw their money, in a kind of self-fulfilling prophecy (or positive feedback loop).

The team went on to show that this positive feedback circuit is switched on in very specific regions in the connective tissue cells, causing proteins to push against only one side of the outer envelope of the cell, eventually causing movement in one preferred direction. Predictably, two important protein components of this signaling circuit, called Ras and PI3K, are often mutated in cancer. This suggests that misregulation of this circuit may increase the invasiveness of cancer cells. It also highlights the need to understand how signaling proteins interact with each other inside cells, hopefully leading one day to new therapies for cancer and other deadly diseases.

This study, entitled "The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts" was published online in Molecular Biology of the Cell on May 15. It is supported by a grant from the Ministry of Education.

Catherine Kolf | EurekAlert!
Further information:
http://www.jhmi.edu

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Supersensitive through quantum entanglement

28.06.2017 | Physics and Astronomy

X-ray photoelectron spectroscopy under real ambient pressure conditions

28.06.2017 | Physics and Astronomy

Mice provide insight into genetics of autism spectrum disorders

28.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>