Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Two Pathways in the Cell Interact to Spur Tumor Growth

31.03.2011
Inactivation of two pathways that regulate cell division profoundly disrupts cell-cycle control and leads to tumor growth, according to researchers from the University of Illinois at Chicago College of Medicine.

The researchers describe how the two pathways interact to produce their combined effect in a study in the journal Genes and Development that is available online.

Tumor growth occurs upon disruption of the regulation of the cell cycle, the cascade of events that result in the division and duplication of a cell. One critical pathway regulating the cell cycle is the retinoblastoma (Rb) tumor suppressor pathway. The Rb pathway is found to be mutated or functionally inactivated in nearly all human cancers.

Maxim Frolov, UIC associate professor of biochemistry and molecular genetics, models development of human cancer by studying inactivation of Rb in fruit flies. In flies, a deficiency in the Rb pathway alone, he says, surprisingly causes only subtle defects in cell proliferation, but does not result in a full-blown tumor.

"We wanted to understand why,” he said.

One possible explanation was that other regulatory pathways were working together with the Rb pathway. In their previous studies, the researchers had found a pathway called Hippo, which seemed to work with Rb in regulation of cell proliferation.

In the new study, Frolov and his colleagues showed that simultaneously inactivating both pathways led to a marked enhancement of tumor growth. The researchers were able to trace the mechanism responsible for the synergy between these two pathways. They found that inactivation of the Hippo and Rb pathways results in an up-regulaton of a unique set of genes.

“We saw that the genes important to cell proliferation and cell cycle regulation are inappropriately expressed in these cells,” Frolov said. The genes were not up-regulated when either the Rb or Hippo pathway alone was inactivated.

“We found that transcription factors -- proteins that turn genes on and off -- involved in each of the two pathways cooperate in inducing expression of these cell-cycle specific genes, resulting in inappropriate cell proliferation,” he said.

The way Hippo is able to cross-talk with the Rb pathway and disrupt cell-cycle regulation to grow tumors may have important implications for understanding the complexity of mutations in human cancers, Frolov said. The finding suggests that there may be other factors that work with Rb to promote tumor growth.

"We should be looking for more cooperating mutations in human cancers,” he said.

The work is the result of international collaboration between Frolov’s laboratory at UIC and Nuria Lopez-Bigas’s genomics group at the University of Pompeu Fabra in Barcelona, Spain. Brandon Nicolay and Battuya Bayarmagnai of UIC's department of biochemistry and molecular genetics and Abul B.M.M.K. Islam of the University Pampeu Fabra contributed to the study. Funding was provided by grants from the National Institutes of Health and the Spanish Ministerio de Educacion y Ciencia and Agència de Gestió d'Ajuts Universitaris i de Recerca of the Catalonian government and from a scholar award from the Leukemia and Lymphoma Society and a NIH National Research Service Award.

For more information about UIC, visit www.uic.edu

NOTE: Please refer to the institution as the University of Illinois at Chicago on first reference and UIC on second reference. "University of Illinois" and "U. of I." are often assumed to refer to our sister campus in Urbana-Champaign.

Jeanne Galatzer-Levy | Newswise Science News
Further information:
http://www.uic.edu

More articles from Life Sciences:

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

nachricht CWRU researchers find a chemical solution to shrink digital data storage
22.06.2017 | Case Western Reserve University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>