The paper is an outgrowth of a meeting the group held at the Banbury Conference Centre in Cold Spring Harbor, N.Y., to discuss the crisis and it appears in the journal Nature Reviews Microbiology.
The group notes that in Europe in 2007, the number of infections by multidrug-resistant bacteria was 400,000 and there were 25,000 attributable deaths.
In the United States alone, antibiotic-resistant infections are responsible for $20 billion per year in excess health care costs, $35 billion per year in societal costs and 8 million additional hospital stays per year.
The problem of resistance is compounded by the fact that we live in a global economy, resulting in a worldwide spread of antibiotic-resistant genes.
The Banbury group recommends that research priorities be established to control resistance.
They point out that additional basic information about resistance is required to address the crisis.
"Increasing lines of evidence identify the principal reservoirs of resistance genes to be bacteria that live in and on humans and animals, as well as those found in the environment (in soil, water and so on)," the paper notes. "However, there is insufficient information about the conditions and factors that lead to the mobilization, selection and movement of these bacteria into and between animal and human populations."
The report also calls for increased international funding to enable scientists to track new antibiotic-resistance threats worldwide, in a manner similar to how the World Health Organization and other agencies track influenza out breaks.
The paper points out that antibiotic resistance is life-threatening in the same sense as cancer, both in the number of cases and the likely outcome. It therefore calls for a public education campaign about bacteria and antibiotic resistance similar to those that have been mounted for cancer awareness.
The study also notes that in some parts of the world, population density, the uncontrolled use of antibiotics, a lack of both a clean water supply and proper treatment for sewage and industrial effluent create the conditions that disseminate and select resistant bacteria.
"Local governments must be encouraged and supported to invest in better sanitation infrastructure and tighter prescription regulations to control the rapid evolution of resistance," the scientists said. "This is a worldwide, multinational problem and must be treated as such."
The group also notes that it is essential to develop a continuous supply of new antibiotics that are not affected by known or existing mechanisms of resistance. The economics of pharmaceutical drug development offer little incentive for companies to develop new antibiotics, since the drugs are used on an episodic, rather than continual, basis. New public-private partnerships must develop to overcome the economics barriers facing the development o new antibiotics.
The Banbury participants also call for better control of antibiotic use, repurposing of old antibiotics to battle resistance and new alternatives to antibiotics.
The group's paper concludes, "The cost of the undertaking that we propose will be infinitesimally small in comparison to the economic and human cost of doing nothing."
Shahriar Mobashery | EurekAlert!
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy