Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Over-organizing repair cells set the stage for fibrosis

20.10.2014

The excessive activity of repair cells in the early stages of tissue recovery sets the stage for fibrosis by priming the activation of an important growth factor, according to a study in The Journal of Cell Biology.

Myofibroblasts are highly contractile cells that repair damaged tissues by replacing and reorganizing the extracellular matrix (ECM), the meshwork that fills the space around cells, in order to draw a wound closed.


Compared with a control skin wound (left), the ECM within a wound containing increased numbers of myofibroblasts (right) is more consistently organized into linear fibers, which increases the activation and release of a growth factor that promotes fibrosis.

Credit: Klingberg et al., 2014

When myofibroblasts are not properly regulated, however, they continue to act on healed tissues and produce excessive amounts of ECM. Excessive ECM production is involved in conditions such as fibrosis, the development of damaging scar tissue in organs.

Transforming growth factor β1 (TGF-β1) is a key signaling molecule within the ECM that promotes tissue fibrosis. Boris Hinz and colleagues previously found that myofibroblasts pull on inactive TGF-β1 complexes to release the active form of the signaling molecule from the ECM.

The University of Toronto researchers then wanted to find out whether the structural changes that myofibroblasts make in the ECM during wound healing might also make it easier for the ECM to release activated growth factor later in the process.

The researchers found that wounds containing increased numbers of myofibroblasts exhibited much higher levels of ECM organization, with components arranged into long, thin fibers. Hinz and colleagues then devised a series of experiments to test how this highly organized ECM configuration affects TGF-β1 activation.

They found that higher levels of organization and tension in the ECM always resulted in high amounts of activated TGF-β1 being released by the contractile force of myofibroblasts.

Their results indicate that, over time, as myofibroblasts remodel and stiffen the ECM during wound healing, the matrix becomes a loaded "mechanical spring" that puts strain on TGF-β1 complexes, causing them to be easily pulled apart and activated by contracting myofibroblasts.

Because TGF-β1 induces further myofibroblast activity and, ultimately, tissue fibrosis, limiting ECM reorganization during wound healing might therefore be an effective therapeutic approach to prevent fibrosis.

###

Klingberg, F., et al. 2014. J. Cell Biol. doi:10.1083/jcb.201402006

About The Journal of Cell Biology

The Journal of Cell Biology (JCB) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JCB content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works, and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit http://www.jcb.org.

Research reported in the press release was supported by the Canadian Institutes of Health Research, the Collaborative Health Research Program, the Canada Foundation for Innovation and Ontario Research Fund, the Heart and Stroke Foundation Ontario, and the European Union's Seventh Framework Program.

Rita Sullivan King | Eurek Alert!

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>