Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Outsmarting Killer Bacteria

15.09.2010
TAU develops next generation of antibiotics to combat drug-resistant "superbugs"

Antibiotics can work miracles, knocking out common infections like bronchitis and tonsillitis. But according to the Center for Disease Control, each year 90,000 people in the U.S. die of drug-resistant "superbugs" — bacteria like Staphylococcus aureus (MRSA), a deadly form of staph infection resistant to normal antibiotics. Although hospital patients are particularly susceptible as a result of open wounds and weakened immune systems, the bacteria can infect anyone.

Dr. Micha Fridman of Tel Aviv University's Department of Chemistry is now developing the next generation of antibiotics designed to overcome this kind of bacteria. And the key, he says, is in the bacteria itself.

"We took the mechanism of bacterial resistance and used this mechanism itself to generate antibiotics," explains Dr. Fridman. "It's thanks to these bacteria that we can develop a better medication." Conducted in collaboration with Prof. Sylvie Garneau-Tsodikova from the University of Michigan at Ann Arbor, Dr. Fridman's research was highlighted recently in the journal ChemBioChem.

Fighting from within

According to Dr. Fridman, certain bacterial strains include enzymes which help the bacteria to inactivate antibiotics. When the enzymes meet with these antibiotics, they chemically alter the drug, making the antibiotic ineffective and unable to recognize its target.

Turning this powerful mechanism against the bacteria itself, the team isolated the antibiotic-inactivating enzymes from the bacteria, then integrated them into the drugs. With this alteration, the modified antibiotics proved to be effective against typically resistant bacterial strains.

At the heart of this development, says Dr. Fridman, was the chemical modification of the parent drug. Once the researchers identified how the bacteria incapacitated the antibiotics, they were able to create a drug that could block bacterial resistance while maintaining the integrity of the antibiotic.

Killing bacteria, saving lives

These new antibiotics will be a vast improvement on today's drugs, says Dr. Fridman. When fully developed, they could be used to treat infections that are now considered difficult if not impossible to treat with current antibiotics.

Dr. Fridman says that, while the new antibiotics are a few years away from the marketplace, the ability to beat bacterial resistance will be invaluable for the future of health care.

George Hunka | EurekAlert!
Further information:
http://www.aftau.org

More articles from Life Sciences:

nachricht Molecular libraries for organic light-emitting diodes
24.04.2017 | Goethe-Universität Frankfurt am Main

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Fraunhofer HHI with latest VR technologies at NAB in Las Vegas

24.04.2017 | Trade Fair News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>