This example of how advanced computational tools are being applied to genome-scale metabolic modeling in microbes illustrates the important contributions from the field of Systems Biology, as highlighted in a special research section in Industrial Biotechnology, a peer-reviewed journal from Mary Ann Liebert Inc., publisher. The articles are available on the Industrial Biotechnology website.
The article "Optimizing Cofactor Specificity of Oxidoreductase Enzymes for the Generation of Microbial Production Strains—OptSwap," by Zachary King and Adam Feist, University of California, San Diego and Technical University of Denmark, Lyngby, describes the development of OptSwap. The authors identified microbial strain designs with significant advantages for the production of L-alanine, succinate, acetate, and D-lactate under the modeled conditions.
"The OptSwap method of King and Feist provides a great example of how systems approaches can enable more effective design and simulation of microbial strains," says Guest Editor Nathan D. Price, PhD, Associate Director, Institute of Systems Biology (Seattle, WA) and a member of the Industrial Biotechnology Editorial Board.
The IB IN DEPTH special section on Systems Biology includes review articles by Kieran Smallbone (University of Manchester, UK) and Pedro Mendes (Virginia Tech, Blacksburg): "Large-Scale Metabolic Models: From Reconstruction to Differential Equations"; Jacob Koskimaki, Anna Blazier, Andres Clarens, and Jason Papin (University of Virginia, Charlottesville): "Computational Models of Algae Metabolism for Industrial Applications"; Scott Harrison and Markus Herrgård (Technical University of Denmark, Hørsholm): "The Uses and Future Prospects of Metabolomics and Targeted Metabolite Profiling in Cell Factory Development"; and Manual Alberto Garcia-Albornoz and Jens Nielsen (Chalmers University of Technology, Göteborg, Sweden): "Application of Genome-Scale Metabolic Models in Metabolic Engineering."
Research articles by Hnin Aung, Susan Henry, and Larry Walker (Cornell University, Ithaca, NY): "Revising the Representation of Fatty Acid, Glycerolipid, and Glycerophospholipid Metabolism in the Consensus Model of Yeast Metabolism,"; and by Patrick Hyland and Radhakrishnan Mahadevan (University of Toronto, Canada) and Serene Lock-Sow Mun (Universiti Teknologi Petronas, Tronoh Malaysia): "Prediction of Weak Acid Toxicity in Saccharomyces cerevisiae Using Genome-Scale Metabolic Models" round out the special section.
About the Journal
Industrial Biotechnology, led by Co-Editors-in-Chief Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY, and Glenn Nedwin, PhD, MoT, CEO and President, Caisson Biotech, LLC, Davis, CA, is an authoritative journal focused on biobased industrial and environmental products and processes, published bimonthly in print and online. The Journal reports on the science, business, and policy developments of the emerging global bioeconomy, including biobased production of energy and fuels, chemicals, materials, and consumer goods. The articles published include critically reviewed original research in all related sciences (biology, biochemistry, chemical and process engineering, agriculture), in addition to expert commentary on current policy, funding, markets, business, legal issues, and science trends. Industrial Biotechnology offers the premier forum bridging basic research and R&D with later-stage commercialization for sustainable biobased industrial and environmental applications.
About the Publisher
Mary Ann Liebert Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in promising areas of science and biomedical research, including Environmental Engineering Science and Sustainability: The Journal of Record. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert Inc., publishers website.
Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 http://www.liebertpub.com Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740
Vicki Cohn | EurekAlert!
Signaling Pathways to the Nucleus
19.03.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
In monogamous species, a compatible partner is more important than an ornamented one
19.03.2018 | Max-Planck-Institut für Ornithologie
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
19.03.2018 | Physics and Astronomy
19.03.2018 | Materials Sciences
19.03.2018 | Event News