Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OptSwap optimizes microbial strain design for production-scale bioprocessing

18.09.2013
Using a new in silico method called OptSwap scientists can predict how to engineer microorganisms to increase the yield of high-value biobased chemicals produced by industrial-scale cell factories.

This example of how advanced computational tools are being applied to genome-scale metabolic modeling in microbes illustrates the important contributions from the field of Systems Biology, as highlighted in a special research section in Industrial Biotechnology, a peer-reviewed journal from Mary Ann Liebert Inc., publisher. The articles are available on the Industrial Biotechnology website.

The article "Optimizing Cofactor Specificity of Oxidoreductase Enzymes for the Generation of Microbial Production Strains—OptSwap," by Zachary King and Adam Feist, University of California, San Diego and Technical University of Denmark, Lyngby, describes the development of OptSwap. The authors identified microbial strain designs with significant advantages for the production of L-alanine, succinate, acetate, and D-lactate under the modeled conditions.

"The OptSwap method of King and Feist provides a great example of how systems approaches can enable more effective design and simulation of microbial strains," says Guest Editor Nathan D. Price, PhD, Associate Director, Institute of Systems Biology (Seattle, WA) and a member of the Industrial Biotechnology Editorial Board.

The IB IN DEPTH special section on Systems Biology includes review articles by Kieran Smallbone (University of Manchester, UK) and Pedro Mendes (Virginia Tech, Blacksburg): "Large-Scale Metabolic Models: From Reconstruction to Differential Equations"; Jacob Koskimaki, Anna Blazier, Andres Clarens, and Jason Papin (University of Virginia, Charlottesville): "Computational Models of Algae Metabolism for Industrial Applications"; Scott Harrison and Markus Herrgård (Technical University of Denmark, Hørsholm): "The Uses and Future Prospects of Metabolomics and Targeted Metabolite Profiling in Cell Factory Development"; and Manual Alberto Garcia-Albornoz and Jens Nielsen (Chalmers University of Technology, Göteborg, Sweden): "Application of Genome-Scale Metabolic Models in Metabolic Engineering."

Research articles by Hnin Aung, Susan Henry, and Larry Walker (Cornell University, Ithaca, NY): "Revising the Representation of Fatty Acid, Glycerolipid, and Glycerophospholipid Metabolism in the Consensus Model of Yeast Metabolism,"; and by Patrick Hyland and Radhakrishnan Mahadevan (University of Toronto, Canada) and Serene Lock-Sow Mun (Universiti Teknologi Petronas, Tronoh Malaysia): "Prediction of Weak Acid Toxicity in Saccharomyces cerevisiae Using Genome-Scale Metabolic Models" round out the special section.

About the Journal

Industrial Biotechnology, led by Co-Editors-in-Chief Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY, and Glenn Nedwin, PhD, MoT, CEO and President, Caisson Biotech, LLC, Davis, CA, is an authoritative journal focused on biobased industrial and environmental products and processes, published bimonthly in print and online. The Journal reports on the science, business, and policy developments of the emerging global bioeconomy, including biobased production of energy and fuels, chemicals, materials, and consumer goods. The articles published include critically reviewed original research in all related sciences (biology, biochemistry, chemical and process engineering, agriculture), in addition to expert commentary on current policy, funding, markets, business, legal issues, and science trends. Industrial Biotechnology offers the premier forum bridging basic research and R&D with later-stage commercialization for sustainable biobased industrial and environmental applications.

About the Publisher

Mary Ann Liebert Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in promising areas of science and biomedical research, including Environmental Engineering Science and Sustainability: The Journal of Record. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert Inc., publishers website.

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 http://www.liebertpub.com Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740

Vicki Cohn | EurekAlert!
Further information:
http://www.liebertpub.com

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>