The scientists working with Prof. Henning Stahlberg at the Biozentrum of the University of Basel have now identified the complete 3D structure of a particular potassium channel, a HCN channel.
3D model of several HCN potassium channels arranged side by side.
University of Basel
This enabled them to draw conclusions about its mechanism of action, which they describe in the current issue of “Nature Communications”.
Neurons conduct information by way of electrical impulses through our body. Potassium channels are a key component of this electrical circuit and are controlled either by an electrical impulse or through signaling molecules. In man, the dysfunction of the so-called HCN potassium channels is associated with neurological disorders such as epilepsy and depression. Prof. Henning Stahlberg’s team at the Biozentrum of the University of Basel has now elucidated the full structure of a bacterial counterpart of this type of potassium channel, which has provided new insights into its functioning.
Based on the analysis of these structures, they discovered, contrary to popular belief, that the pore always remains open. “When the signaling molecule cAMP docks onto the potassium channel, it causes a rearrangement and shift in the protein scaffold,” explains Julia Kowal, first author of this study. “We think that cAMP in fact widens the filter somewhat, thereby controlling the flow of potassium ions.” The newly uncovered structural details have made it possible for the researchers to consider the mode of functioning of these channels from a new perspective.Mechanism relevant for new drugs
Katrin Bühler | Universität Basel
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