The scientists working with Prof. Henning Stahlberg at the Biozentrum of the University of Basel have now identified the complete 3D structure of a particular potassium channel, a HCN channel.
3D model of several HCN potassium channels arranged side by side.
University of Basel
This enabled them to draw conclusions about its mechanism of action, which they describe in the current issue of “Nature Communications”.
Neurons conduct information by way of electrical impulses through our body. Potassium channels are a key component of this electrical circuit and are controlled either by an electrical impulse or through signaling molecules. In man, the dysfunction of the so-called HCN potassium channels is associated with neurological disorders such as epilepsy and depression. Prof. Henning Stahlberg’s team at the Biozentrum of the University of Basel has now elucidated the full structure of a bacterial counterpart of this type of potassium channel, which has provided new insights into its functioning.
Based on the analysis of these structures, they discovered, contrary to popular belief, that the pore always remains open. “When the signaling molecule cAMP docks onto the potassium channel, it causes a rearrangement and shift in the protein scaffold,” explains Julia Kowal, first author of this study. “We think that cAMP in fact widens the filter somewhat, thereby controlling the flow of potassium ions.” The newly uncovered structural details have made it possible for the researchers to consider the mode of functioning of these channels from a new perspective.Mechanism relevant for new drugs
Katrin Bühler | Universität Basel
Molecular Spies to Fight Cancer - Procedure for improving tumor diagnosis successfully tested
03.08.2015 | Helmholtz-Zentrum Dresden-Rossendorf
Stroke: news about platelets
03.08.2015 | Julius-Maximilians-Universität Würzburg
Glacier decline in the first decade of the 21st century has reached a historical record, since the onset of direct observations. Glacier melt is a global phenomenon and will continue even without further climate change. This is shown in the latest study by the World Glacier Monitoring Service under the lead of the University of Zurich, Switzerland.
The World Glacier Monitoring Service, domiciled at the University of Zurich, has compiled worldwide data on glacier changes for more than 120 years. Together...
Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.
What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...
Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.
The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...
Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.
Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight
A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...
23.07.2015 | Event News
10.07.2015 | Event News
25.06.2015 | Event News
03.08.2015 | Materials Sciences
03.08.2015 | Life Sciences
03.08.2015 | Life Sciences