Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU team discovers powerful molecule regulator in blood pressure control system

12.03.2010
The research, published in the Journal of Neuroscience Research, sheds light on what determines availability of the molecules involved in blood pressure control

Researchers at Oregon Health & Science University's School of Dentistry (www.ohsu.edu/sod) have discovered that nitric oxide is a powerful regulator of a molecule that plays a critical role in the development and function of the nervous system. The finding could someday play a significant role in the prevention and treatment of high blood pressure, which affects about one in three adults in the United States.

The new discovery is published online (http://www3.interscience.wiley.com/cgi-bin/fulltext/123189946/PDFSTART) and will appear in the May issue of the Journal of Neuroscience Research.

Changes in blood pressure are signaled to the brain by nerve cells called baroreceptors. The OHSU dental school team previously found that baroreceptors make a molecule called brain-derived neurotrophic factor (BDNF), which belongs to the family of neurotrophins that play a critical role in the development and plasticity of other nerve cells.

The OHSU dental school team found that nitric oxide is a potent regulator of BDNF in baroreceptor neurons. Nitric oxide is known for its ability to improve the elasticity of blood vessels and to lower blood pressure. It is the active metabolite of nitroglycerin, which has been used to treat coronary artery disease for more than 100 years. Nitric oxide widens small arteries and counteracts artery stiffening, and several lines of evidence also indicate that its deficiency leads to hypertension.

"This is the first study to show the role of nitric oxide in inhibiting BDNF release from peripheral nerve cells," said Agnieszka Balkowiec, M.D., Ph.D., principal investigator, associate professor of integrative biosciences in the OHSU School of Dentistry, and adjunct assistant professor of physiology and pharmacology in the OHSU School of Medicine. "This finding supports our hypothesis that BDNF is involved in establishing connections in the blood pressure control system and could someday play a significant role in the prevention of high blood pressure."

Additional study authors include Hui-ya Hsieh, B.S.; Carolyn Robertson, M.D.; and Anke Vermehren-Schmaedick, Ph.D.

The study was supported by grants from the American Heart Association and the National Institutes of Health's National Heart, Lung, and Blood Institute, including the American Recovery and Reinvestment Act (ARRA) funds.

Dr. Balkowiec teaches physiology and neuroscience to first-year dental students and is often an invited lecturer in dental school courses on orofacial pain. Since 2004 the dental school has received more than $16.4 million in research funding.

About OHSU

Oregon Health & Science University is the state's only health and research university and Oregon's only academic health center. OHSU is Portland's largest employer and the fourth largest in Oregon (excluding government), with 12,700 employees. OHSU's size contributes to its ability to provide many services and community support activities not found anywhere else in the state. It serves patients from every corner of the state, and is a conduit for learning for more than 3,400 students and trainees. OHSU is the source of more than 200 community outreach programs that bring health and education services to every county in the state.

Sydney Clevenger | EurekAlert!
Further information:
http://www.ohsu.edu

More articles from Life Sciences:

nachricht Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>