Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU Oregon National Primate Research Center develops new, safer method for making vaccines

30.05.2012
While vaccines are perhaps medicine's most important success story, there is always room for improvement. Researchers at Oregon Health & Science University's Oregon National Primate Research Center (ONPRC) appear to have done just that.

As explained in a newly published research paper, Mark Slifka, Ph.D., and colleagues have discovered a new method for creating vaccines that is thought to be safer and more effective than current approaches. The research results are published online in the journal Nature Medicine.

"Most vaccines have an outstanding safety record," explained Slifka. "It is important to keep in mind that no medical achievement has saved more lives than the simple act of vaccination. However, for many diseases, we have struggled to develop an effective vaccine. In other cases, vaccines may be protective, but come with rare but serious side effects. For instance, the live oral polio vaccine was very effective at stopping polio outbreaks and transmission, but was also responsible for eight to 10 cases of vaccine-associated polio in the United States each year.

This problem was solved in 2000 when the U.S. switched to a formaldehyde-fixed 'dead' form of the vaccine. Our goal is to make vaccines like these safer and potentially even more effective by pioneering an entirely new approach to vaccine development."

Slifka's approach is remarkable because it is the first to demonstrate that hydrogen peroxide can inactivate viruses for use as vaccines. Although hydrogen peroxide has long been known as an effective antiseptic and is often used to sterilize medical equipment, it was believed that it would be too damaging to be useful in vaccine development. It turns out that this previous notion was incorrect. In fact, peroxide may turn out to be one of the best new approaches to future vaccine design.

In the study published this week, Slifka's lab generated not one, but three vaccines.

"We wanted to demonstrate that this is truly a platform technology and not just a one-hit-wonder," explained Slifka. "For this reason, we chose three unrelated model systems and demonstrated protective vaccine-induced immunity in all three cases."

The three diseases targeted by these viruses are West Nile virus, Lymphocytic choriomeningitis virus (a relative of lassa fever virus, known to cause hemorrhagic fever in Africa) and vaccinia virus (widely known for its previous use in the smallpox vaccine.)

An Oregon-based biotech company, Najít Technologies, Inc., is hoping that these advances in vaccine technology will result not only in new vaccines but also new jobs in the Portland area.

"This new approach really gives a boost to an area of vaccine development that's been stagnant for some time," said Ian Amanna, Ph.D., associate vice president for research at Najít Technologies.

"Because of these advances, we've been increasing our workforce and putting together a group of very talented researchers. In partnership with OHSU, we're excited to have the opportunity to further develop this technology into commercial vaccines that can offer protection for at-risk individuals. These vaccines will not only be important to international travelers, but also to the people living in endemic regions. These places are often in developing countries with limited resources for preparing and testing life-saving vaccines and we are looking forward to the day that we can bring these new vaccines to the countries that need them the most."

Najít Technologies, founded by Slifka and colleagues using methods first discovered at OHSU, hopes to continue working together with academic institutions such as OHSU, ONPRC, and Washington University-St. Louis to create new and better vaccines for some of the world's biggest problems including West Nile virus, yellow fever and dengue hemorrhagic fever.

Grants from the National Institutes of Health and ONPRC supported the research.

Conflict of Interest Statement

OHSU and Dr. Slifka have a financial interest in Najit Technologies, Inc., a company that may have a commercial interest in the results of this research and technology. This potential individual and institutional conflict of interest has been reviewed and managed by OHSU.
About OHSU
Oregon Health & Science University is the state's only health and research university, and only academic health center. As Portland's largest employer, OHSU's size contributes to its ability to provide many services and community support activities not found anywhere else in the state. OHSU serves patients from every corner of the state and is a conduit for learning for more than 4,300 students and trainees. OHSU is the source of more than 200 community outreach programs that bring health and education services to each county in the state. OHSU is home to ONPRC, one of the eight National Primate Research Centers in the U.S.
About NTI
Najít Technologies, Inc. is a privately-held vaccine development company founded in 2004. The company is headquartered in Beaverton, OR. The Mission of the company is to develop safe and effective vaccines against infectious diseases of global importance. Some of the information presented here may contain projections or other forward-looking statements regarding the future. These statements are only predictions and are subject to risks and uncertainties that could cause results to differ from those expressed or implied statements.

Jim Newman | EurekAlert!
Further information:
http://www.ohsu.edu

More articles from Life Sciences:

nachricht Study suggests oysters offer hot spot for reducing nutrient pollution
17.10.2017 | Virginia Institute of Marine Science

nachricht World first for reading digitally encoded synthetic molecules
17.10.2017 | CNRS

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Study suggests oysters offer hot spot for reducing nutrient pollution

17.10.2017 | Life Sciences

Breaking: the first light from two neutron stars merging

17.10.2017 | Physics and Astronomy

World first for reading digitally encoded synthetic molecules

17.10.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>