The research team, led by Hong Wang, PhD, created mice with a deficiency of lipoprotein lipase (LPL) in neurons, and observed two important reactions. First, the mouse models ate less and second, they became sedentary. Because LPL is important to the delivery of fatty acids to the brain, these responses spotlight the importance of fatty acid delivery to the brain in the regulation of body weight.
“This work may have important impact in understanding the causes of obesity and providing new treatments for this epidemic of our time,” said Robert H. Eckel, MD, corresponding and senior author of “Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity” which was published today in Cell Metabolism.
The genetically-modified mouse (NEXLPL) has a defect in the breakdown of dietary lipoprotein triglycerides into fatty acids in the brain. These mice became obese on a standard chow diet between three and six months. At that point, the mice ate less and were less active.
The research also looked at which areas of the brain have the greatest impact on regulating body weight and learned that the hypothalamus may be the key area to observe as NEXLPL mice have increases in hypothalamic AgRP/NPY gene expression before obesity. AgRP/NPY cause increases in food intake and decreases in energy expenditure. Researchers also noted that the NEXLPL mice demonstrate deficiencies in n-3 fatty acids in the hypothalamus. Overall, this research indicates that the lipoproteins are sensed in the brain by an LPL-dependent pathway and provide lipid signals for the central regulation of body weight and energy balance.
The research team included scientists in the Division of Endocrinology, Metabolism and Diabetes in the Department of Medicine at the CU School of Medicine; the Department of Pharmacology at the University of California Irvine; the Department of Neurogenetics at the Max-Planck-Institute of Experimental Medicine in Germany; the Italian Institute of Technology in Genoa, Italy and the Department of Medicine at Columbia University in New York.
Faculty at the University of Colorado’s School of Medicine work to advance science and improve care. These faculty members include physicians, educators and scientists at University of Colorado Hospital, The Children’s Hospital, Denver Health, National Jewish Health, and the Denver Veterans Affairs Medical Center. Degrees offered by the University of Colorado School of Medicine include doctor of medicine, doctor of physical therapy, and masters of physician assistant studies. The School is located on the University of Colorado’s Anschutz Medical Campus, one of four campuses in the University of Colorado system. For additional news and information, please visit the UC Denver newsroom online.
Contact: Jacque Montgomery, 303-928-9093, firstname.lastname@example.org
Jacque Montgomery | EurekAlert!
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences