Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NYU Researchers Identify Process Producing Neuronal Diversity in Fruit Flies’ Visual System

29.08.2014

New York University biologists have identified a mechanism that helps explain how the diversity of neurons that make up the visual system is generated.

“Our research uncovers a process that dictates both timing and cell survival in order to engender the heterogeneity of neurons used for vision,” explains NYU Biology Professor Claude Desplan, the study’s senior author.

The study’s other co-authors were: Claire Bertet, Xin Li, Ted Erclik, Matthieu Cavey, and Brent Wells—all postdoctoral fellows at NYU.

Their work, which appears in the latest issue of the journal Cell, centers on neurogenesis—the process by which neurons are created.

A central challenge in developmental neurobiology is to understand how progenitors—stem cells that differentiate to form one or more kinds of cells—produce the vast diversity of neurons, glia, and non-neuronal cells found in the adult Central Nervous System (CNS).

Temporal patterning is one of the core mechanisms generating this diversity in both invertebrates and vertebrates. This process relies on the sequential expression of transcription factors into progenitors, each specifying the production of a distinct neural cell type.

In the Cell paper, the researchers studied the formation of the visual system of the fruit fly Drosophila. Their findings revealed that this process, which relies on temporal patterning of neural progenitors, is more complex than previously thought.

They demonstrate that in addition to specifying the production of distinct neural cell type over time, temporal factors also determine the survival or death of these cells as well as the mode of division of progenitors.

Thus, temporal patterning of neural progenitors generates cell diversity in the adult visual system by specifying the identity, the survival, and the number of each unique neural cell type.

The research was supported, in part, by a grant from the National Institutes of Health (R01 EY017916).

James Devitt | newswise
Further information:
http://www.nyu.edu

Further reports about: CNS Cell Drosophila NYU Neuronal Visual diversity neural neurons temporal transcription vertebrates

More articles from Life Sciences:

nachricht Bugs life: The nerve cells that make locusts 'gang up'
17.12.2014 | University of Leicester

nachricht New class of synthetic molecules mimics antibodies
17.12.2014 | Yale University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Smart Cities

08.12.2014 | Event News

European Polymer Congress 2015 in Dresden/Germany

01.12.2014 | Event News

Regional economic cooperation in Central Asia

21.11.2014 | Event News

 
Latest News

'Perfect Storm' Quenching Star Formation around a Supermassive Black Hole

18.12.2014 | Physics and Astronomy

Choreography of an electron pair

18.12.2014 | Physics and Astronomy

'Sugar-coated' microcapsule eliminates toxic punch of experimental anti-cancer drug

18.12.2014 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>