Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NYU, Harvard chemists create bipedal, autonomous DNA walker

06.04.2009
Device mimics role of cell's transportation system

Chemists at New York University and Harvard University have created a bipedal, autonomous DNA "walker" that can mimic a cell's transportation system.

The device, which marks a step toward more complex synthetic molecular motor systems, is described in the most recent issue of the journal Science. For a video demonstration of the walker, go to http://www.nyu.edu/public.affairs/videos/qtime/biped_movie.mov.

Two fundamental components of life's building blocks are DNA, which encodes instructions for making proteins, and motor proteins, such as kinesin, which are part of a cell's transportation system. In nature, single strands of DNA—each containing four molecules, or bases, attached to backbone—self-assemble to form a double helix when their bases match up. Kinesin is a molecular motor that carries various cargoes from one place in the cell to another. Scientists have sought to re-create this capability by building DNA walkers.

Earlier versions of walkers, which move along a track of DNA, did not function autonomously, thereby requiring intervention at each step. A challenge these previous devices faced was coordinating the movement of the walker's legs so they could move in a synchronized fashion without falling off the track.

To create a walker that could move on its own, the NYU and Harvard researchers employed two DNA "fuel strands" (purple and green in the above video). These fuel strands push the walker (blue) along a track of DNA, thereby allowing the walker and the fuel strands to function as a catalytic unit.

The forward progress of the system is driven by the fact that more base pairs are formed every step—a process that creates the energy necessary for movement. As the walker moves along the DNA track, it forms base pairs. Simultaneously, the fuel strands move the walker along by binding to the track and then releasing the walker's legs, thereby allowing the walker to take "steps".

The track's length is 49 nanometers—if the track was one meter long, an actual meter, enlarged proportionally, would be the approximate diameter of the earth.

The walker was created in the laboratory of NYU Chemistry Professor Nadrian Seeman, one of the article's co-authors. The paper's other authors were Tosan Omabegho, a doctoral candidate at Harvard's School of Engineering and Applied Sciences, and Ruojie Sha, a senior research associate in the NYU Chemistry Department.

James Devitt | EurekAlert!
Further information:
http://www.nyu.edu

More articles from Life Sciences:

nachricht Are there sustainable solutions in dealing with dwindling phosphorus resources?
16.10.2017 | Leibniz-Institut für Nutzierbiologie (FBN)

nachricht Strange undertakings: ant queens bury dead to prevent disease
13.10.2017 | Institute of Science and Technology Austria

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

Im Focus: Small collisions make big impact on Mercury's thin atmosphere

Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.

Recent modeling along with previously published results from NASA's MESSENGER spacecraft -- short for Mercury Surface, Space Environment, Geochemistry and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

Conference Week RRR2017 on Renewable Resources from Wet and Rewetted Peatlands

28.09.2017 | Event News

 
Latest News

A single photon reveals quantum entanglement of 16 million atoms

16.10.2017 | Physics and Astronomy

The melting ice makes the sea around Greenland less saline

16.10.2017 | Earth Sciences

On the generation of solar spicules and Alfvenic waves

16.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>