The research, reported in the latest issue of the Proceedings of the National Academy of Sciences (PNAS), could yield valuable methods for making pharmaceuticals and other chemicals that require precise assembly of complex structures.
The NYU team performs studies in "biomimetic chemistry." This research pursues synthetic molecules with structures and functions resembling molecules found in nature. Many biological molecules, such as proteins and DNA, can fold themselves into ordered helices and bundles.
Within the past decade, scientists have successfully synthesized molecular chains that can also fold into various shapes. Although these "foldamers" resemble biochemical forms, finding mimics of biochemical functions has been more elusive. Now, the NYU chemists are able to create folded molecules that can perform a complex function. In this case, the new molecules are catalysts—substances that speed up the rate of chemical transformations.
The PNAS paper describes how to embed a catalytic chemical group within a larger twisted architecture. The researchers' hypothesis was that the arrangement of the surrounding twist would help determine how contacts could be made between the catalyst and surrounding molecules. To test the functionality of their foldamer, they combined it with a pair of mirror-image molecules—those with identical composition, but whose atoms are distributed in opposing spatial locations, much like left-handed and right-handed gloves—to determine if it could correctly interact with one of the pair in order to form a new chemical. The ability of the foldamer to do so was evidence of its precision.
"Our molecules are particularly interesting in that they are 'selective'—they will recognize one type of target molecule and catalyze its chemical conversion," explained NYU Chemistry Professor Kent Kirshenbaum, one of the study's authors. "This is especially important for making complex chemical structures, so we think this may be eventually useful for the synthesis of new drugs."
"Molecules used in pharmaceuticals have to be manufactured in an extremely specific manner," he added. "The difference in resulting chemicals between two mirror-image molecules could be enormous, so it is crucial that a catalyst correctly make a distinction between similar structures. Once we learn the rules to connect different molecular folds to desired functions, there should be many new tricks and new tasks we can teach our molecules to perform."
The study's other authors were NYU Chemistry Professors Michael Ward, who is also the department's chair, and post-doctoral fellow Galia Maayan. All three are also part of NYU's Molecular Design Institute. For more on NYU's Molecular Design Institute, go to: http://www.nyu.edu/fas/dept/chemistry/mdi/
Not of Divided Mind
19.01.2017 | Hertie-Institut für klinische Hirnforschung (HIH)
CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy