Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NUS Researchers Developed World’s First Fluorescent Sensor to Detect Common Illicit Date Rape Drug Within Seconds

31.03.2014

A team of researchers from the National University of Singapore (NUS) has developed the world’s first fluorescent sensor to identify the presence of a drug known as GHB that is commonly used to spike beverages. When the sensor is mixed with a sample of a beverage containing GHB, the mixture changes colour in less than 30 seconds, making detection of the drug fast and easy.

This simple mix-and-see discovery, led by Professor Chang Young-Tae of the Department of Chemistry at the NUS Faculty of Science, is a novel scientific breakthrough that contributes towards prevention of drug-facilitated sexual assault problems.


National University of Singapore

GHB Orange, the fluorescent sensor for detecting date rape drug GHB (bottle in top left), under UV light with the drug GHB (bottle in top right), and when it was mixed into red wine without GHB (vial in front left) and with GHB (vial in front right)

The findings were first published in the journal Chemical Communications earlier this year.

GHB: notorious drug used in drink spiking

... more about:
»Drug »NUS »Sensor »Singapore »colour »drink »fluorescent

Gamma-hydroxybutyric acid, commonly known as GHB, is a central nervous system depressant that has been used in the medical setting as a general anaesthetic. In the 1990s, it gained notoriety as a drug allegedly used in instances of drink spiking. Today, it is one of the most commonly used date rape drugs, rendering the victim incapacitated and vulnerable to sexual assault.

As GHB is odourless, colourless and slightly salty, it is almost undetectable when mixed in a drink, thus making it desirable to sexual predators. A small amount of between two to four grams of GHB will interfere with the motor and speech control of a person, and may even induce a coma-like sleep. GHB takes effect within 15 to 30 minutes, and the effect can last for three to six hours. It is only detectable in urine six to 12 hours after ingestion.

Novel fluorescent sensor to detect GHB

Fluorescent dyes have been widely used as sensors for analytical purposes because of their high sensitivity, fast response time and technical simplicity.

Under the supervision of Prof Chang, the team of researchers, comprising Dr Zhai Duanting, a Research Fellow, Mr Xu Wang, a PhD candidate, as well as Mr Elton Tan, a recent graduate, of the Department of Chemistry at the NUS Faculty of Science, screened 5,500 dyes generated from different fluorescent scaffolds. These fluorescent scaffolds have been used to construct the Diversity Oriented Fluorescence Library (DOFL) that was developed by Prof Chang over the last decade.

The team shortlisted 17 fluorescent compounds and further tested them with a wide range of different GHB concentrations. Through this, the team identified that an orange fluorescent compound, coined GHB Orange, changes colour when it is mixed with GHB.

In order to examine the efficiency of GHB Orange, the team tested its detection capability by mixing a small amount of it with samples of various beverages, ranging from alcoholic, non-alcoholic, coloured and colourless drinks, which contain GHB. The test revealed differences in the fluorescence intensity between GHB-free and GHB-spiked beverages. For drinks that are translucent or of a light colour, such as water or vodka, the change in colour can be easily detected with the naked eye. The change in the colour of darker drinks, such as Cola and whiskey, requires the aid of additional lighting to better detect the change.

Remarkably, this detection can be done through a simple mix-and-see process, which takes less than 30 seconds.

Future plans

While GHB Orange has proven to be efficient in detecting GHB in beverages, there is a need to develop a test kit that is convenient for users to use and carry around. Prof Chang and his team intend to work with industry partners to develop a handy and cheap device for GHB detection.

Carolyn FONG | newswise
Further information:
http://www.nus.edu.sg

Further reports about: Drug NUS Sensor Singapore colour drink fluorescent

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>